(Theme 5) Below are data from Jimenez et al (2022) depicting cellular expression patterns of the tumor suppressor transcription factor p53 (a gene commonly mutated in cancers). They explored oscillating expression patterns found in a mutated human cell line. Panel D shows measurements of changes in p53 mRNA levels measured using two different approaches; figure E shows measurements of protein levels from the same samples. The numbers on either side indicate the observed fold change (FC) in relative abundance of these molecules (note that any difference in values obtained between the two methods are not relevant for this question). D E RNASeq FC qPCR FC 1.5 0.5 p53 1.5 1 0.5 0 1 2 3 4 5 6 7 8 9 time [h] MassSpec FC WB FC 5 4 2 p53 1. 1 0 1 2 3 4 5 6 7 8 9 time [h] A) Propose an explanation for how the magnitude of protein changes can be larger than the changes in mRNA.
(Theme 5) Below are data from Jimenez et al (2022) depicting cellular expression patterns of the tumor suppressor transcription factor p53 (a gene commonly mutated in cancers). They explored oscillating expression patterns found in a mutated human cell line. Panel D shows measurements of changes in p53 mRNA levels measured using two different approaches; figure E shows measurements of protein levels from the same samples. The numbers on either side indicate the observed fold change (FC) in relative abundance of these molecules (note that any difference in values obtained between the two methods are not relevant for this question). D E RNASeq FC qPCR FC 1.5 0.5 p53 1.5 1 0.5 0 1 2 3 4 5 6 7 8 9 time [h] MassSpec FC WB FC 5 4 2 p53 1. 1 0 1 2 3 4 5 6 7 8 9 time [h] A) Propose an explanation for how the magnitude of protein changes can be larger than the changes in mRNA.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Gene Interactions
When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.
Gene Expression
Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.
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Answer part a
![(Theme 5) Below are data from Jimenez et al (2022) depicting cellular
expression patterns of the tumor suppressor transcription factor p53 (a
gene commonly mutated in cancers). They explored oscillating expression
patterns found in a mutated human cell line. Panel D shows measurements
of changes in p53 mRNA levels measured using two different approaches;
figure E shows measurements of protein levels from the same samples. The
numbers on either side indicate the observed fold change (FC) in relative
abundance of these molecules (note that any difference in values obtained
between the two methods are not relevant for this question).
D
E
RNASeq FC
qPCR FC
1.5
1
0.5
p53
1.5
0.5
0 1 2 3 4 56789
time [h]
MassSpec FC
WB FC
5
2
p53
0 1 2 3 4 5 6 7 8 9
time [h]
A) Propose an explanation for how the magnitude of protein changes can be
larger than the changes in mRNA.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F4143f45a-5c96-4449-af2f-abda697f3e91%2F089ac713-34d1-4ee1-aea4-236966caafc0%2Fof5fzvs_processed.png&w=3840&q=75)
Transcribed Image Text:(Theme 5) Below are data from Jimenez et al (2022) depicting cellular
expression patterns of the tumor suppressor transcription factor p53 (a
gene commonly mutated in cancers). They explored oscillating expression
patterns found in a mutated human cell line. Panel D shows measurements
of changes in p53 mRNA levels measured using two different approaches;
figure E shows measurements of protein levels from the same samples. The
numbers on either side indicate the observed fold change (FC) in relative
abundance of these molecules (note that any difference in values obtained
between the two methods are not relevant for this question).
D
E
RNASeq FC
qPCR FC
1.5
1
0.5
p53
1.5
0.5
0 1 2 3 4 56789
time [h]
MassSpec FC
WB FC
5
2
p53
0 1 2 3 4 5 6 7 8 9
time [h]
A) Propose an explanation for how the magnitude of protein changes can be
larger than the changes in mRNA.
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