Concept explainers
At the end of an article on how mutations in variable number tandem repeat (VNTR) sequences of DNA are associated with disease, Krontiris (1995, p. 1683) writes: “The VNTR mutational process may actually be positively selected; by culling those of us in middle age and beyond, evolution brings our species into fighting trim.” (T.G. Krontiris.1995, “Minisatellites and Human Disease.” Science 269, Reprinted with permission of the AAAS).
This researcher proposes that natural selection on humans favors individuals who die relatively early in life. His logic is that the trait of dying from VNTR mutations is beneficial and should spread because the population as a whole becomes younger and healthier as a result. Can this hypothesis be true, given that selection acts on individuals? Explain.
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Evolutionary Analysis (5th Edition)
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- You are discussing with some of your bio major friends who have not taken Genetics and your non-bio major friends about how characteristics such as blue eye, light skin pigmentation, and light hair color, derived from a mutation that occurred about 10,000 years ago in Europe. Your friends are not very happy that you used the word mutation to describe the origin of human characteristics associated with light pigmentation. At that moment you only recall that green eye, fair skin and red hair in Neanderthals was due to other alleles and you mention that to them as an example of genetic determinants in species of the genus Homo. They are not convinced of your choice of the word mutation. Then you remember part of one of the papers that you read for Minicourse 5 regarding the OCA2 allele. “OCA2, homologous to the mouse pink-eyed dilution gene, encodes the human protein P, an integral membrane protein involved in both the transport of tyrosine and that helps in the regulation of…arrow_forward"The Quest to Create a Synthetic Human Genome" Define this ?arrow_forwardHow many different explanations can you think of for the observation that the rate of mutation varies across the genome? How would you weigh up evidence for these different ideas to decide which ones have the most explanatory power?arrow_forward
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