a.
To determine: The way by which disorder inherited with well-defined reasons.
Introduction: The genetic abnormalities which are transmitted from parents to the offsprings and then to their grandsons or granddaughters are referred to as the genetic disorders. Genetic diseases may be of two main types, the sex chromosomal and the autosomal derived diseases.
b.
To determine: The genotypes for many individuals in the given pedigree as possible.
Introduction: Dominant abnormalities are those who express their defects in their progenies dominantly. However, the recessive abnormalities can skip the generations as a healthy dominant gene can suppress the behavior of the recessive character.
c.
To determine: The expected proportion containing all unaffected children from the four unaffected children of parents III-4 and III-5.
Introduction: From the pedigree, if a cross is made between the affected and non-affected parents, the progenies produced as a result of the cross will be of both types, the dominant as well as the recessive type. Recessive progenies will be healthy that do not carry the abnormal genes. However, the dominant progenies will carry the diseased genes.
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Introduction to Genetic Analysis
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- . The pedigree below was obtained for a rare kidney disease.a. Deduce the inheritance of this condition, stating your reasons. b. If persons 1 and 2 marry, what is the probability that their first child will have the kidney disease?arrow_forwardA couple who are about to get married learn from studying their family histories that, in both their families, theirunaffected grandparents had siblings with cystic fibrosis(a rare autosomal recessive disease).a. If the couple marries and has a child, what is theprobability that the child will have cystic fibrosis?b. If they have four children, what is the chance that thechildren will have the precise Mendelian ratio of 3:1 fornormal:cystic fibrosis?c. If their first child has cystic fibrosis, what is theprobability that their next three children will be normal?arrow_forwardPEDIGREE: Shaded individuals in the pedigree have a genetic disease. Individuals marrying into the family, that is individuals II–1, II–4 and II–6, have no history of the disease in their families.1. Determine the mode of inheritance ______________________________2. Give the genotypes of the following individualsarrow_forward
- A young couple went to see a genetic counselor because each had a sibling affected with cystic fibrosis. (Cystic fibrosis is a recessive disease, and neither member of the couple nor any of their four parents is affected.) a. What is the probability that the female of this couple is a carrier? b. What are the chances that their child will be affected with cystic fibrosis? c. What is the probability that their child will be a carrier of the cystic fibrosis mutation?arrow_forwardBelow is a pedigree of a family with a rare genetic disorder. I. IV. a. What is the mode of inheritance for this rare disorder and what is the genotype of I.1 and 1.2? b. Write the genotypes for the following individuals (if the genotype is unknown write all possible genotypes): i.) III.2 - ii) III.3 -arrow_forwardA woman with a rare autosomal recessive disorder was told that it was unlikely that her children would have the disorderas her husband did not have it. However, her first child has the disorder. a. What is the most likely explanation? b. Diagram the cross between the woman and her husband using a Punnett square, give the genotypic ratio (GR) and phenotypic ratio (PR) from the Punnett square. c. Based on the Punnett square results, what is the chance that her next child will have the disorder?arrow_forward
- Assume that one of Merida's sons, who is heterozygous for orange hair color, married a girl that was also heterozygous. Create a Punnett square to show the possibilities that would result if they had children. a. List the possible genotypes and phenotypes for their children. b. What are the chances of a child with orange hair? c. What are the chantes of a child with yellow?arrow_forwardDuchenne muscular dystrophy is sex linked and usually affects only males. Victims of the disease become progressively weaker, starting early in life.a. What is the probability that a woman whose brother has Duchenne’s disease will have an affected child?b. If your mother’s brother (your uncle) had Duchenne’s disease, what is the probability that you have received the allele?c. If your father’s brother had the disease, what is the probability that you have received the allele?arrow_forwardPlease consider the following pedigree. Assume that people who marry in to the family do not carry the allele unless otherwise indicated. Assume complete penetrance. image attached a. Is it possible for the inheritance pattern for the trait illustrated in this pedigree to be as a result of each of the following? Answer yes or no. (i) an autosomal recessive allele (AR)(ii) an autosomal dominant allele (AD)(iii) a X-linked recessive allele (XR)(iv) a X-linked dominant allele (XD) b. Provide a set of parents that definitively supports your answers in (a).arrow_forward
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