Introduction to Genetic Analysis
Introduction to Genetic Analysis
11th Edition
ISBN: 9781464109485
Author: Anthony J.F. Griffiths, Susan R. Wessler, Sean B. Carroll, John Doebley
Publisher: W. H. Freeman
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Chapter 2, Problem 50P

a.

Summary Introduction

To determine: The way by which disorder inherited with well-defined reasons.

Introduction: The genetic abnormalities which are transmitted from parents to the offsprings and then to their grandsons or granddaughters are referred to as the genetic disorders. Genetic diseases may be of two main types, the sex chromosomal and the autosomal derived diseases.

b.

Summary Introduction

To determine: The genotypes for many individuals in the given pedigree as possible.

Introduction: Dominant abnormalities are those who express their defects in their progenies dominantly. However, the recessive abnormalities can skip the generations as a healthy dominant gene can suppress the behavior of the recessive character.

c.

Summary Introduction

To determine: The expected proportion containing all unaffected children from the four unaffected children of parents III-4 and III-5.

Introduction: From the pedigree, if a cross is made between the affected and non-affected parents, the progenies produced as a result of the cross will be of both types, the dominant as well as the recessive type. Recessive progenies will be healthy that do not carry the abnormal genes. However, the dominant progenies will carry the diseased genes.

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Please answer all of them, they are all connected. PEDIGREE ANALYSIS and SYMBOLOGY: Examine the pedigree which has X linked Dominant inheritance of disorder. Use letter X* (asterisk denotes disorder) as genotype of the individuals which can be XX, XY, X*X*, X*X and X*Y. a. What is the genotype of IV-6? b. What is the genotype of III-6? c. What is the genotype of II-3? d. What is the genotype of III-8? e. If couple I-1 and I-2 will have a son, what is the probability of having the disorder? f. If couple III-8 and III-9 will have another child, what is the probability of having the disorder? g. Theoretically, if individual IV-3 and individual IV-5 will marry and will have a child, what is the probability of having a child without the X-linked disorder?
Examine the pedigree and answer the following questions; shaded individuals show the trait; genotypes are all unknown. The individual marked with the question mark is of an unknown genotype but does have the trait. A. What mode of inheritance is the most likely for this trait, autosomal recessive or autosomal dominant? State your rationale for full credit. B. What is the genotype of the individual marked with the question mark? (Heterozygous, homozygous, or unknown)
Examine the pedigree and answer the following questions; shaded individuals show the trait; genotypes are all unknown. The individual marked with the question mark is of an unknown genotype but lacks the trait. A. What mode of inheritance is the most likely, autosomal recessive or autosomal dominant? State your rationale for full credit. B. What is the genotype of the individual designated with the question mark? (Heterozygous, homozygous, or unknown). C. What are the genotypes of the parents in generation I? (Heterozygous, homozygous, or unknown). D. What are the genotypes of the three children of generation IV? (Heterozygous, homozygous, or unknown).

Chapter 2 Solutions

Introduction to Genetic Analysis

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