Concept explainers
a.
To determine: The most likely mode of inheritance of the disease.
Introduction: Autosomal indicates the errors that happen on chromosome 1..22, preferably than on the 23rd sex-linked X chromosome. Also, the X-linked dominant genetic disorders concerning the 23rd X chromosome. Some models of autosomal dominant disorders are Huntington's disease and achondroplasia that is dwarfism.
b.
To determine: The genotype of each family member.
Introduction: The autosomal dominant inheritance model in an autosomal dominant disorder, the mutated gene is a dominant gene found on one of the nonsex chromosomes that are autosomes.
c.
To determine: Advice the three couples in the third generation about the likelihood of having an affected child as a family's doctor.
Introduction: Autosomal dominant is a feature or disorder that can be carried within families. In an autosomal dominant disorder, if one receives the abnormal gene from just one parent and can perceive the illness. Frequently, one of the parents also possesses the disease.
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Introduction to Genetic Analysis
- A young couple went to see a genetic counselor because each had a sibling affected with cystic fibrosis. (Cystic fibrosis is a recessive disease, and neither member of the couple nor any of their four parents is affected.) a. What is the probability that the female of this couple is a carrier? b. What are the chances that their child will be affected with cystic fibrosis? c. What is the probability that their child will be a carrier of the cystic fibrosis mutation?arrow_forwardA couple who are about to get married learn from studying their family histories that, in both their families, theirunaffected grandparents had siblings with cystic fibrosis(a rare autosomal recessive disease).a. If the couple marries and has a child, what is theprobability that the child will have cystic fibrosis?b. If they have four children, what is the chance that thechildren will have the precise Mendelian ratio of 3:1 fornormal:cystic fibrosis?c. If their first child has cystic fibrosis, what is theprobability that their next three children will be normal?arrow_forwardDuchenne muscular dystrophy is sex linked and usually affects only males. Victims of the disease become progressively weaker, starting early in life.a. What is the probability that a woman whose brother has Duchenne’s disease will have an affected child?b. If your mother’s brother (your uncle) had Duchenne’s disease, what is the probability that you have received the allele?c. If your father’s brother had the disease, what is the probability that you have received the allele?arrow_forward
- 15. The following pedigree shows inheritance of Huntington's disease, a fatal genetic disorder that causes neurodegeneration. Since signs and symptoms usually do not appear until adulthood, many who are carriers may not realize their risk of passing on the disease-causing allele. The following pedigree represents a family in which some people are affected by Huntington's disease. Reeessive Trit er btmnt be Mec yplicalty Hinheteearrow_forwardSickle cell anemia is an inherited red blood cell disorder in which there are not enough healthy red blood cells to carry oxygen throughout the body. The allele that causes sickle-cell anemia is autosomal recessive (s), and the dominant allele can be represented by S. How many offspring will be affected by the disorder if the mother is a carrier, and the father appears to be normal? (Include the gender) a. b. How many will become carriers? (include the gender) A- 三三三 四 四 II !!arrow_forwardA young couple went to see a genetic counselor because each had a sibling with cystic fibrosis. (Cysticfibrosis is a recessive disease, and neither member ofthe couple nor any of their four parents is affected.)a. What is the probability that the female of thiscouple is a carrier?b. What are the chances that their child will havecystic fibrosis?c. What is the probability that their child will be acarrier of the cystic fibrosis disease allele?arrow_forward
- The condition phenylketonuria is caused by a recessive allele. There are two carriers who have progeny.a. Give the gene notation. b. Give the expected genotypic and phenotypic ratios. c. What is the probability that their child will be heterozygous if they have a normal child?d. What is the probability of having two affected children and one normal child if they have three children?arrow_forwardDuchenne muscular dystrophy (DMD) is an example of an X-linked trait. This is a neuromuscular disease that causes muscles to slowly dehydrate, leading to paralysis. The disease allele is recessive (Xd) and the normal allele is dominant (XD). A female that is a carrier for DMD has kids with a normal male. Complete this cross on scratch paper and then answer the questions. A. What is the chance (%) that these two parents will have a kid with DMD? B. Their first child is a son. What is the chance (%) that he will have DMD? Hint: Look at only the male offspring when you answer this question.arrow_forwardPEDIGREE: Shaded individuals in the pedigree have a genetic disease. Individuals marrying into the family, that is individuals II–1, II–4 and II–6, have no history of the disease in their families.1. Determine the mode of inheritance ______________________________2. Give the genotypes of the following individualsarrow_forward
- Examine the pedigree and answer the following questions; shaded individuals show the trait; genotypes are all unknown. The individual marked with the question mark is of an unknown genotype but does have the trait. A. What mode of inheritance is the most likely for this trait, autosomal recessive or autosomal dominant? State your rationale for full credit. B. What is the genotype of the individual marked with the question mark? (Heterozygous, homozygous, or unknown)arrow_forwardExamine the pedigree and answer the following questions; shaded individuals show the trait; genotypes are all unknown. The individual marked with the question mark is of an unknown genotype but lacks the trait. A. What mode of inheritance is the most likely, autosomal recessive or autosomal dominant? State your rationale for full credit. B. What is the genotype of the individual designated with the question mark? (Heterozygous, homozygous, or unknown). C. What are the genotypes of the parents in generation I? (Heterozygous, homozygous, or unknown). D. What are the genotypes of the three children of generation IV? (Heterozygous, homozygous, or unknown).arrow_forward17. Parents Jacob and Emma have had two children, Samuel and Matthew. Baby Samuel died at the age of nine days. When baby Matthew has trouble feeding, his parents take him in to the doctor. He is diagnosed with Maple Syrup Urine Disease (MSUD), a life-threatening condition in which the patient is not able to break down proteins from 19 their food. As Matthew receives treatment, Jacob and Emma are referred to a genetic counselor. The genetic counselor collects information about their family. Neither of Jacob's parents were affected by MSUD. Jacob had one brother and three sisters. One of these sisters died shortly after birth. Similarly, neither of Emma's parents were affected by MSUD. Emma had four brothers, and two of these died shortly after birth. a. Given what you know about Jacob and Emma's family, construct a pedigree that includes all three generations.arrow_forward
- Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning