Concept explainers
To explain: The effect of an advantageous allele at low frequency, and mutated allele, on the adaption of a large population.
Introduction: Adaptation is the changing in the behavior of an individual for surviving and accommodating the environment, whereas mutation is the change in the DNA sequence of an individual.
To explain: Whether both of the above events are accompanied by a selective sweep.
Introduction: Selective sweep is the result of natural selection where a beneficial but rare allele increases its frequency at a very faster rate and gets fixed in the population for their fitness.
To name: The detection method to study the variation in the DNA sequence near the locus after adaptation occurrence.
Introduction: In populations, variations occur because of different allelic frequencies and mutations. Both the events lead to adaptation and change the sequences of DNA near the locus of the allele. These variations in the sequences could be detected by different analysis methods.
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- Refer to the figure above. In their investigation of natural selection on Mc1r alleles (the gene that determines coat color) in Arizona pocket mice, Hoekstra et al. determined the frequency of the D and d alleles in each population. They also determined the frequency of alleles for two neutral mitochondrial DNA genes (genes that do not affect and are not linked to coat color). Why did the researchers include the mitochondrial DNA genes as part of their experimental design? Allele change for the neutral mitochondrial genes serves as an experimental group and gives information on any general background genetic difference among these populations. Allele change for the neutral mitochondrial genes serves as a control and determines coat-color differences among these populations. Allele change for the neutral mitochondrial genes serves as an experimental group and gives information on coat-color differences among these populations. Allele…arrow_forwardThis is a graph of the expected frequency of a deleterious allele, with a constant mutation rate, within a population at different levels of selection against it. 0.000012 0.00001 0.000008 0.000006 0.000004 0.000002 0.2 0.4 0.6 0.8 H = 10 i) What is the overall trend shown? ii) What is the mutation-selection balance? iii) The formula for the equilibrium frequency of a deleterious allele within a population is p^=u/s where u is the mutation rate and s is the selection coefficient. Using the relationships illustrated by this formula, determine the following for a population with two deleterious alleles A and B: a) If A has a high mutation rate and low selection coefficient, and B has a low mutation rate and a medium selection coefficient, which would deleterious allele would be expected to be seen in higher frequency? b) If both A and B have a similar selection coefficient, but B is seen at a higher frequency than A, which allele likely has the highest mutation rate? c) If both A and B…arrow_forwardSuppose that a population is at equilibrium between mutation and selection for a deleterious recessive allele, where s = 0.5 and μ = 10−5. What is the equilibrium frequency of the allele? What is the selection cost?arrow_forward
- The forward mutation rate for piebald spotting in guinea pigs is 8 × 10-5;the reverse mutation rate is 2 × 10-6. If no other evolutionary forces areassumed to be acting, what is the expected frequency of the allele forpiebald spotting in a population that is in mutational equilibrium?arrow_forwardIn a very large population, if the forward and reverse mutation rates are exactly the same, how would you expect the frequency of an original, non-mutated allele to change in the population over time? Will the population eventually achieve an equilibrium value of the frequency of the non-mutated allele?arrow_forwardApply the VIDA table to the evolution of sickle cell disease to justify whether it is an instance of evolution by natural selection. Answer the following questions. Is there variation in this trait in the population? How exactly does it vary? Is the trait at least partly inherited? Is there selection for this trait in a particular environment? (What is the selective pressure? And how does a trait give an advantage or disadvantage in that environment?) What is the evidence that this trait makes organisms better adapted to their environment?arrow_forward
- Recently, scientists have identified a mutation that is found at high frequency in Finnish populations, located in northern Europe where the winter is very cold. This mutation is believed to be a “cold sensitive” allele that warns people of extreme cold temperatures. Could this allele have undergone a “selective sweep”, if it had suddenly appeared in this northern population of humans? How would such a selective sweep be detected with genome data?arrow_forward1) This model shows the process of natural selection on rabbits demonstrating variation in fur color over several generations. Using the model, what most likely led to the loss of white furred rabbits in the population? 21 A) XB) 9) The white rabbits did not reproduce fast enough to survive. White was a recessive trait and therefore not passed on to any offspring. The white fur was a favorable trait but was never prevalent in the population. The rabbits with white fur had less camouflage in D) the environment and were more easily preyed on by predators. If this model continues, with no major changes to the environment,arrow_forwardLet’s suppose the mutation rate for converting a B allele into a ballele is 10−4 per generation. The current allele frequencies areB = 0.6 and b = 0.4. How long will it take for the allelefrequencies to equal each other, assuming that no genetic drifttakes place?arrow_forward
- According to the Hardy-Weinberg law of equilibrium: Question 1 options: A) In absence of mutation and natural selection, the frequencies of the genotypes will remain stable because no evolutionary change takes place. B) In absence of gene flow, the frequencies of the genotypes will remain stable because no evolutionary change takes place. C) In absence of genetic drift, the frequencies of the genotypes will remain stable because no evolutionary change takes place. D) All of the above. E) None of the above.arrow_forwardThis model shows the process of natural selection on rabbits demonstrating variation in fur color over several generations. Using the model, what most likely led to the loss of white furred rabbits in the population? A) the white rabbits did not reproduce fast enough to survive B) white was a recessive trait and therefore not passed on to any offspring C) the white fur was a favorable trait but was never prevalent in the population D) the rabbits with white fur had less camouflage in the environment and were more easily preyed on by predatorsarrow_forwardPINE TREE NEEDLES Variation among members of a population can lead to natural selection, but only if two conditions are met: First, the trait must be relevant to an individual's survival and/or reproductive rate. Second, variation in this trait must be heritable, that is, at least partly controlled by genes. a. How might you design an experiment to determine the importance of needle length in determining survival and reproduction? b. How might you test the extent to which needle length is heritable?arrow_forward
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