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Based on new research iPSC-derived cardiovascular progenitor cells successfully seeded a decellularized mouse heart and differentiated into cardiomycocytes, smooth muscle, and endothelial cells. The reason behind ECM would have direct influence of differentiation of progenitor cells into these varied types.
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Progenitor cells are distinguished from stem cells as they are early descendants of stem cells, which can differentiate to form one or more kinds of cells, and have limited ability to replicate in vivo or in vitro and their restricted differentiation capacity. Heart diseases are leading cause of death worldwide. Numerous research studies are focusing on heart tissue engineering by creating heart tissues.
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Developmental Biology
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- question: Summarize the following in concise and understandable language. Nanotechnology Tools to Inactivate SARS-CoV-2 in Patients The main target of SARS-CoV-2 is the respiratory tract (upper airways, lung), although other organs might also be infected (e.g., gut, kidney) and vasculature also appears to be a prime target. The expression of ACE2 probably determines uptake by different tissues. In addition to discussing immune-based approaches, because the lung is the most critically affected organ, we will center our discussion on the various options to inactivate the virus in the deep lung and to target the essential host cells for drug delivery. The virus reaches the alveoli and enters alveolar epithelial type II cells (AECII), due to the relatively high abundance of ACE2 and a permissive cellular milieu. These cells serve as a reservoir of the virus, which finally spreads throughout the lung, leading to the lung function impairment seen in severe cases. Airborne nanomaterials are…arrow_forwardDate Pre-Lab Exercise 12-3 Pathway of Blood Flow through the Heart Answer the following questions about the pathway of blood flow through the heart. Use your textbook and Exercise 12-1 in this unit for reference. 1. Regarding veins: a. Where do veins carry blood? deoxygenated? b. Is this blood generally oxygenated or c. Does this rule have any exceptions? If yes, where? 2. Regarding arteries: a. Where do arteries carry blood? Is this blood generally oxygenated or deoxygenated? c. Does this rule have any exceptions? If yes, where? 3. Where does each atrium pump blood when it contracts? Right atrium: a. b. Left atrium: 4. Where does each ventricle pump blood when it contracts? a. Right ventricle: b. Left ventricle:arrow_forwardTask 1 In what physiological conditions the heart is regulated by the Frank-Starling law?arrow_forward
- Biology (MindTap Course List)BiologyISBN:9781337392938Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. BergPublisher:Cengage Learning