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- Below are two cell signalling pathways that work together to regulate cell growth, proliferation and ultimately the size of organs in O.Extremus. In other closely related organisms, dysfunction of these pathways has been associated with tumor growth. MTOR pathway: 1. Growth factors bind and stimulate the receptors. crosstalk Hippo Pathway 2. Receptors can activate the phosphatidylinositol 3 kinase (PI3K) – Akt signaling pathway. MTOR Pathway 3. The activated Akt, a serine threonine kinase, inhibits theTSC1-TSC2 complex, allowing Rheb to activate mTORC1. Mst PI3K PTEN Lats АКТ 4. In parallel, amino acids activate the mTORC1 pathway through a mechanism requiring the Rag- Ragulator complex. miR-29 YAP TSC2-TSC1 amino acids Rag-Ragulator Hippo pathway: 1. The binding of the ligand activates the receptors which activate Mst and Lats. Rheb cell division MTORC1 organ size 2. YAP activity is modulated by phosphorylation of Mst and Lats. YAP upregulates miR-29, which in turn downregulates PTEN, an inhibitor of PI(3)K and Akt. So, the two pathways crosstalk and cell growth Created in BioRender.com coordinate cell number and growth. b) Which signalling pathway in the above diagram utilizes this forward reaction? Circle the correct answer. MTOR pathway Hippo pathway Both pathways Neither pathway

- Below are two cell signalling pathways that work together to regulate cell growth, proliferation and ultimately the size of organs in O.Extremus. In other closely related organisms, dysfunction of these pathways has been associated with tumor growth. MTOR pathway: 1. Growth factors bind and stimulate the receptors. crosstalk Hippo Pathway 2. Receptors can activate the phosphatidylinositol 3 kinase (PI3K) – Akt signaling pathway. MTOR Pathway 3. The activated Akt, a serine threonine kinase, inhibits theTSC1-TSC2 complex, allowing Rheb to activate mTORC1. Mst PI3K PTEN Lats АКТ 4. In parallel, amino acids activate the mTORC1 pathway through a mechanism requiring the Rag- Ragulator complex. miR-29 YAP TSC2-TSC1 amino acids Rag-Ragulator Hippo pathway: 1. The binding of the ligand activates the receptors which activate Mst and Lats. Rheb cell division MTORC1 organ size 2. YAP activity is modulated by phosphorylation of Mst and Lats. YAP upregulates miR-29, which in turn downregulates PTEN, an inhibitor of PI(3)K and Akt. So, the two pathways crosstalk and cell growth Created in BioRender.com coordinate cell number and growth. b) Which signalling pathway in the above diagram utilizes this forward reaction? Circle the correct answer. MTOR pathway Hippo pathway Both pathways Neither pathway

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Practice Question 8 - Below are two cell signalling pathways that work together to regulate cell growth, proliferation and ultimately the size of organs in O.Extremus. In other closely related organisms, dysfunction of these pathways has been associated with tumor growth. mTOR pathway: 1. Growth factors bind and stimulate the receptors. crosstalk Hippo Pathway 2. Receptors can activate the phosphatidylinositol 3 kinase (PI3K) – Akt signaling pathway. MTOR Pathway - 3. The activated Akt, a serine threonine kinase, inhibits theTSC1–TSC2 complex, allowing Rheb to activate mTORC1. Mst РІЗК PTEN Lats АКТ 4. In parallel, amino acids activate the mTORC1 pathway through a mechanism requiring the Rag- ator con miR-29 YAP TSC2-TSC1 lex. amino acids Rag-Ragulator Hippo pathway: 1. The binding of the ligand activates the receptors which activate Mst and Lats. Rheb cell division MTORC1 organ size 2. YAP activity is modulated by phosphorylation of Mst and Lats. YAP upregulates miR-29, which in turn downregulates PTEN, an inhibitor of PI(3)K and Akt. So, the two pathways crosstalk and cell growth Created in BioRender.com cordinate cell number and growth. b) Which signalling pathway in the above diagram utilizes this forward reaction? Circle the correct answer. MTOR pathway Hippo pathway Both pathways Neither pathway
Transcribed Image Text:Practice Question 8 - Below are two cell signalling pathways that work together to regulate cell growth, proliferation and ultimately the size of organs in O.Extremus. In other closely related organisms, dysfunction of these pathways has been associated with tumor growth. mTOR pathway: 1. Growth factors bind and stimulate the receptors. crosstalk Hippo Pathway 2. Receptors can activate the phosphatidylinositol 3 kinase (PI3K) – Akt signaling pathway. MTOR Pathway - 3. The activated Akt, a serine threonine kinase, inhibits theTSC1–TSC2 complex, allowing Rheb to activate mTORC1. Mst РІЗК PTEN Lats АКТ 4. In parallel, amino acids activate the mTORC1 pathway through a mechanism requiring the Rag- ator con miR-29 YAP TSC2-TSC1 lex. amino acids Rag-Ragulator Hippo pathway: 1. The binding of the ligand activates the receptors which activate Mst and Lats. Rheb cell division MTORC1 organ size 2. YAP activity is modulated by phosphorylation of Mst and Lats. YAP upregulates miR-29, which in turn downregulates PTEN, an inhibitor of PI(3)K and Akt. So, the two pathways crosstalk and cell growth Created in BioRender.com cordinate cell number and growth. b) Which signalling pathway in the above diagram utilizes this forward reaction? Circle the correct answer. MTOR pathway Hippo pathway Both pathways Neither pathway
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