Concept explainers
To explain: The reason why a dicentric chromosome is unstable.
Introduction: Dicentric chromosomes are chromosomes with two centromeres. Generally, the chromosomes have only one centromere. Irradiation and genetic events like paracentric inversion and Robertsonian translocation lead to dicentric chromosomes. The dicentric chromosomes can be identified by the presence of tailed nuclei.
To explain: The reason why a backup centromere is not a good thing for chromosome though it gives two chances to form a kinetochore and attaches to microtubules during mitosis.
Introduction: Deoxyribonucleic acid (DNA) is the genetic material carried by every eukaryotic organism. Every DNA is made up of a pair of condensed chromatid subunits and they two are held together at a region called centromere.
To explain: The reason why back up centromere will not help to ensure that the chromosome did not get left behind at mitosis.
Introduction: Every DNA is made up of a pair of condensed chromatid subunits and the two are held together at a region called centromere.
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Molecular Biology of the Cell (Sixth Edition)
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