Concept explainers
(a)
Interpretation:
Whether “citrate enters the inner mitochondrial membrane” occurs in the mitochondrial matrix or in the cytosol in the citrate-malate shuttle system has to be determined.
Concept introduction:
Lipogenesis is the process employed for the synthesis of fatty acid. The starting precursor for the synthesis is acetyl CoA. The enzyme employed for the process is fatty acid synthase. It is a multienzyme complex that ties the reaction responsible for the synthesis of fatty acid.
Acetyl CoA is synthesized in mitochondria and then transported to cytosol through the citrate-malate shuttle system.
(b)
Interpretation:
Whether “production of malate from oxaloacetate” occurs in the mitochondrial matrix or in the cytosol in the citrate–malate shuttle system has to be determined.
Concept introduction:
Lipogenesis is the process employed for the synthesis of fatty acid. The starting precursor for the synthesis is acetyl CoA. The enzyme employed for the process is fatty acid synthase. It is a multienzyme complex that ties the reaction responsible for the synthesis of fatty acid.
Acetyl CoA is synthesized in mitochondria and then transported to cytosol through the citrate-malate shuttle system.
(c)
Interpretation:
Whether “NAD+ is used to convert malate to oxaloacetate” occurs in the mitochondrial matrix or in the cytosol in the citrate–malate shuttle system has to be determined.
Concept introduction:
Lipogenesis is the process employed for the synthesis of fatty acid. The starting precursor for the synthesis is acetyl CoA. The enzyme employed for the process is fatty acid synthase. It is a multienzyme complex that ties the reaction responsible for the synthesis of fatty acid.
Acetyl CoA is synthesized in mitochondria and then transported to cytosol through the citrate-malate shuttle system.
(d)
Interpretation:
Whether “generation of CoA-SH” occur in the mitochondrial matrix or in the cytosol in the citrate–malate shuttle system has to be determined.
Concept introduction:
Lipogenesis is the process employed for the synthesis of fatty acid. The starting precursor for the synthesis is acetyl CoA. The enzyme employed for the process is fatty acid synthase. It is a multienzyme complex that ties the reaction responsible for the synthesis of fatty acid.
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