Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 20, Problem 35P
The following is a partial pedigree of the British royal family. The family contains several inbred individuals and a number of inbreeding pathways. Carefully evaluate the pedigree, and identify the pathways and common ancestors that produce inbred individuals A (Alice in generation IV), B (George VI in generation VI), and C (Charles in generation VIII).
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Draw out a pedigree with 3+ generations that accurately mimics the inheritance patterns for one of the following: Huntington’s disease, sickle cell anemia, or genetic hemophilia. In your pedigree, be sure to properly denote carriers as well as people with the condition. Additionally, include the following, using proper pedigree conventions: a stillbirth and an incidence of inbreeding.
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Chapter 20 Solutions
Genetic Analysis: An Integrated Approach (3rd Edition)
Ch. 20 - 20.1 Compare and contrast the terms in each of the...Ch. 20 - In a population, what is the consequence of...Ch. 20 - 20.3 Identify and describe the evolutionary forces...Ch. 20 - Describe how natural selection can produce...Ch. 20 - Thinking creatively about evolutionary mechanisms,...Ch. 20 - 20.6 Genetic drift, an evolutionary process...Ch. 20 - Over the course of many generations in a small...Ch. 20 - Catastrophic events such as loss of habitat,...Ch. 20 - 20.9 George Udny Yule was wrong in suggesting that...Ch. 20 - 20.10 The ability to taste the bitter compound...
Ch. 20 - Figure 20.6 illustrates the effect of an ethanol ...Ch. 20 - 20.12 Biologists have proposed that the use of...Ch. 20 - 20.13 Two populations of deer, one of them large...Ch. 20 - 20.14 Directional selection presents an apparent...Ch. 20 - 20.15 What is inbreeding depression? Why is...Ch. 20 - 20.16 Certain animal species, such as the...Ch. 20 - Genetic Analysis 20.1 predicts the number of...Ch. 20 - 20.18 In a population of rabbits, and . The...Ch. 20 - Sickle cell disease (SCD) is found in numerous...Ch. 20 - 20.20 Epidemiologic data on the population in the...Ch. 20 - The frequency of tasters and nontasters of PTC...Ch. 20 - Tay-Sachs disease is an autosomal recessive...Ch. 20 - 20.23 Cystic fibrosis (CF) is the most common...Ch. 20 - 20.24 In the mouse, Mus musculus, survival in...Ch. 20 - 20.25 In a population of flowers growing in a...Ch. 20 - Assume that the flower population described in the...Ch. 20 - 20.27 ABO blood type is examined in a Taiwanese...Ch. 20 - 20.28 A total ofmembers of a Central American...Ch. 20 - 20.29 A sample offield mice contains individuals...Ch. 20 - Prob. 30PCh. 20 - Albinism, an autosomal recessive trait...Ch. 20 - 20.32 The frequency of an autosomal recessive...Ch. 20 - 20.33 Evaluate the following pedigree, and answer...Ch. 20 - Evaluate the following pedigree, and answer the...Ch. 20 - The following is a partial pedigree of the British...Ch. 20 - Draw a separate hypothetical pedigree identifying...Ch. 20 - Prob. 37PCh. 20 - 20.38 Achromatopsia is a rare autosomal recessive...Ch. 20 - 20.39 New allopolyploid plant species can arise by...
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- Consider the following pedigree below for a rare autosomal trait. Be sure to take into account the inbreeding convention, when needed. After divorce, individual “A” decides to marry at random outside the pedigree. If the population allele frequency of the rare autosomal trait is 0.012, what are the chances of having an affected child for his first born of his second marriage?arrow_forwardA family tree of sorts is called a pedigree. The symbols used for a pedigree are: female, unaffected female, affected ☐male, unaffected male, affected I 11 III 1 Pedigree Chart Minor Peta #2 Siblings are placed in hirth order from left to right and are labeled with Arabic numerals. Each generation is labeled with a Roman numeral. Therefore, the male exhibiting the trait in the pedigree below in the bottom, center would be identified as III-4. 1. Which members of the family above are affected by Huntington's Disease? 4. How many girls did II-1 and 11-2 have? 3. How many children did individuals 1-1 and 1-2 have? 2. There are no carriers for Huntington's Disease- you either have it or you don't. With this in mind, is Huntington's disease caused by a dominant or recessive trait? 5. How are individuals III-2 and II-4 related? 8 -Huntington's Diseasearrow_forwardGet the genotypic and phenotypic ratio of the following: Dihybrid cross: Harry has 1 pair of dog, he's going to breed his pure black, furry male to his white furless female (P generation). Also, he wants to find out what will be the result if he breed 2 offspring from F1 generation. Help him to predict the P and G ratio of F1 and F2 generation using the Punnett Square.arrow_forward
- Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you decide to have a child if the test results said that you carry the mutation for breast and ovarian cancer? The heart disease mutation? The TSD mutation? The heart disease and the mutant alleles?arrow_forwardPedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. 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Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you want to know the results of the cancer, heart disease, and TSD tests if you were Sarah and Adam? Is it their responsibility as potential parents to gather this type of information before they decide to have a child?arrow_forwardPedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. 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- There are now nearly 200 recognized breeds of dog, from the Affenpinscher to the Yorkshire Terrier. But several of these suffer from medical problems due to the inbreeding required to establish the breed. For example, nearly every Cavalier King Charles (discussed in the Biology and Society essay) suffers from heart murmurs caused by a genetically defective heart valve. Such problems are likely to remain as long as the organizations that oversee dog breeding maintain strict pedigree requirements. Some people are suggesting that every breed be allowed to mix with others to help introduce new gene lines free of the congenital defects. Why do you think the governing societies are resistant to such cross-breed mixing? What would you do if you were in charge of addressing the genetic defects that currently plague some breeds?arrow_forwardIn cattle, coats may be solid white, solid black, or black-and-whitespotted. When true-breeding solid whites are mated with truebreeding solid blacks, the F1 generation consists of all solid white individuals. After many F1 * F1 matings, the following ratio was observed in the F2 generation: 12/16 solid white3/16 black-and-white spotted1/16 solid black Explain the mode of inheritance governing coat color by determining how many gene pairs are involved and which genotypes yield which phenotypes. Is it possible to isolate a true-breeding strain of black-and-white spotted cattle? If so, what genotype would they have? If not, explain why not.arrow_forwardYou have been hired to produce a family tree for three generations of a family where a disorder called “blinky” syndrome is observed. People who suffer from blinky syndrome blink their eyes rapidly when they look at bright lights. In order to draw a pedigree chart for this family, you interview Mike and Annie. Neither suffer from this syndrome. Annie’s mother is normal, while Annie’s father blinked like crazy at bright lights. Annie has one sister and one brother and both of them are unaffected. While Annie’s sister has yet to have kids, her brother married a blinky sufferer. Mike’s mother is a blinker while his father is normal. Mike’s brother is just like their mother. In addition, this brother married a blinker. Mike’s sister is normal - as is her husband and their one boy. Draw a pedigree chart below in order to answer the following on the next page. Use the letters A and a for the genotypes. If more than one genotype is possible for an individual - you may write it as A with a…arrow_forward
- You have been hired to produce a family tree for three generations of a family where a disorder called “blinky” syndrome is observed. People who suffer from blinky syndrome blink their eyes rapidly when they look at bright lights. In order to draw a pedigree chart for this family, you interview Mike and Annie. Neither suffer from this syndrome. Annie’s mother is normal, while Annie’s father blinked like crazy at bright lights. Annie has one sister and one brother and both of them are unaffected. While Annie’s sister has yet to have kids, her brother married a blinky sufferer. Mike’s mother is a blinker while his father is normal. Mike’s brother is just like their mother. In addition, this brother married a blinker. Mike’s sister is normal - as is her husband and their one boy. Draw a pedigree chart below in order to answer the following on the next page. Use the letters A and a for the genotypes. If more than one genotype is possible for an individual - you may write it as A with a…arrow_forwardA dark-red strain and a white strain of wheat are crossed andproduce an intermediate, medium-red F1. When the F1 plants areinterbred, an F2 generation is produced in a ratio of 1 dark-red:4 medium-dark-red: 6 medium-red: 4 light-red: 1 white. Furthercrosses reveal that the dark-red and white F2 plants are truebreeding. How many additive alleles are needed to produce each possiblephenotype?arrow_forwardFrom the pedigree shown here, answer the following questions with regard to individual VII-1. A. Who are the common ancestors of her parents? B. What is the inbreeding coefficient for this individual?arrow_forward
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