Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Chapter 16.5, Problem 1COMQ
Summary Introduction
Introduction:
Epigenetic cells are bound to have cells that cause cancer. There are many ways through which, the cells can cause cancer. Cancer cells are dangerous and cause an abnormality in gene expression and gene regulation. Epigenetic effects causes the cancer cells to pass to cells of the offspring.
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Which of the following may produce more than one functional protein from an mRNA transcript?a. chromatin condensation b. transcriptional regulation c. epigeneticsd. alternative mRNA processing
Epigenetic marks regulate gene expression.
Which epigenetic mark is NOT associated with positive gene expression?
A. Histone acetylation
B. Histone Methylation
C. De-methylated DNA
D. Methylated DNA
Which of the following is an example of chromatin modification that stimulates gene expression?
Group of answer choices
A. alternative exon splicing
b. microRNA binding to mRNA
c. DNA methylation
D. histone acetylation
Chapter 16 Solutions
Genetics: Analysis and Principles
Ch. 16.1 - Which of the following are examples of molecular...Ch. 16.1 - 2. An epigenetic modification to a specific gene...Ch. 16.1 - Prob. 3COMQCh. 16.1 - Epigenetic changes may a. be programmed during...Ch. 16.2 - 1. For the Igf2 gene, where do de novo methylation...Ch. 16.2 - 2. For XCI to occur, where are the Xist and Tsix...Ch. 16.2 - 3. Which of the following possibilities could...Ch. 16.3 - 1. Which of the following statements about...Ch. 16.3 - The effects of paramutation may vary with regard...Ch. 16.4 - 1. When mice carrying theallele exhibit a darker...
Ch. 16.4 - 2. If the VIN3 gene had a loss-of-function...Ch. 16.5 - Prob. 1COMQCh. 16.5 - Prob. 2COMQCh. 16 - Prob. 1CONQCh. 16 - List and briefly describe five types of molecular...Ch. 16 - Prob. 3CONQCh. 16 - What is the key difference between cis and...Ch. 16 - Prob. 5CONQCh. 16 - Prob. 6CONQCh. 16 - 7. Outline the molecular steps in the process of...Ch. 16 - Prob. 8CONQCh. 16 - 9. In general, explain how epigenetic...Ch. 16 - 10. What are the contrasting roles of trithorax...Ch. 16 - Describe the molecular steps by which polycomb...Ch. 16 - Prob. 12CONQCh. 16 - Using coat color in mice and the development of...Ch. 16 - How can environmental agents that do not cause...Ch. 16 - Prob. 15CONQCh. 16 - Prob. 16CONQCh. 16 - Explain how the VIN3/PRC2 complex specifically...Ch. 16 - Prob. 1EQCh. 16 - In the experiments described in Figure 16.8,...Ch. 16 - Prob. 3EQCh. 16 - A research study indicated that an agent in...Ch. 16 - Lets suppose you were interested in developing...Ch. 16 - Prob. 6EQCh. 16 - Prob. 7EQCh. 16 - 2. Discuss the similarities and differences of...
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- Define the following terms: a. epigenetics b. CpG island c. epimutation d. DNA methylation e. histone acetylationarrow_forwardFor each statement below indicate whether it is true or false: A. Strand discrimination during the process of DNA repair is based on DNA methylation B. The genetic code has 64 amino acid-specifying codons C. Mutations in germline cells are more consequential to subsequent generations than mutations in somatic cells.arrow_forwardWhich of the following is NOT a description of an epigenetic modification? A. regulatory patterns that persisis in the absence of the original signal B. stable alterations in gene expression without changes to the underlying DNA sequence C. the persistence of gene expression patterns through cell division D. an intrinsic signal that triggers cell differentiationarrow_forward
- Which of the following is not a major mechanism of epigenetic change? a. DNA methylation b. Alteration of a DNA base sequence in a promoter c. Histone acetylation d. Action of RNA moleculesarrow_forwardPost-translational modifications of proteins can affect which of the following? a. protein function b. transcriptional regulation c. chromatin modification d. all of the abovearrow_forwardEpigenesis relating to genetics refers to which of the following A. Genetic information is limited to what we inherit only from our biological parents. B. Genes are not influenced by environmental factors. C. Genes we inherit are fully expressed at birth. D. Genes are turned on or off as needed, by the developing body or environmental triggers, across the life-spanarrow_forward
- Which of the following statements concerning p53 is NOT correct? O a. p53-dependent transcription of target genes leads to cell cycle arrest or cell death (apoptosis). O b. O C. Loss of p53 function results in loss of checkpoint controls. Loss of p53 function creates an environment that is permissive for genome instability--that is, more damaged cells with chromosome aberrations and mutations survive and propagate. d. p53 is a tumor suppressor protein which is largely responsible for protecting cells from cancer- causing DNA-damaging agents.arrow_forwardThe BRCA genes produce DNA repair proteins. Genetic testing is available that can determine if a person has a mutation in the BRCA genes that makes the proteins less able to function. What is the result of a BRCA mutation? A. The person is more likely to develop cancer if other DNA in the cell mutates. B. The person is less likely to develop cancer unless the BRCA region is methylated. C. The person is less likely to develop cancer because the BRCA gene will inhibit the cell cycle checkpoints. D. The person is more likely to develop cancer because the BRCA gene promotes an increased rate for mitosis.arrow_forwardSome cancers have been treated with drugs that demethylate DNA.Explain how these drugs might work. Do you think the cancer-causinggenes that responded to the demethylation are likely to have beenoncogenes or tumor-suppressor genes? Explain your reasoning.arrow_forward
- Cancer cells removed from a patient's tumor have increased gene expression of several hundred genes (including many cancer-causing genes). Scientists determine that the histones from the cancer cells have an overall/average lower affinity for DNA than histones from normal control cells. Which drug is most likely to help treat this patient's cancer? a. An inhibitor for HMT (histone methyltransferases) b. An inhibitor for HDM (histone demethylases) c. An inhibitor for HDACs (histone deacetylases) d. An inhibitor for HATs (histone acetyltransferase)arrow_forwardFrom the list of answers (A-D) below, select the correct anwer(s). There may be more than one answer. B. During the process of cell division all epigenetic changes are lost. A. Epigenetic changes survive cell division. C. Epigenetic changes have NO role in cell differentiation. D. Each of the 200 types have the same genome, but distinct epigenome, which is important for the process of cell differentiation.arrow_forwardIn eukaryotes, chromatin remodeling plays an important role is gene regulation. This is because a. repositioning of the nucleosomes makes DNA accessible to transcription regulatory proteins b. the nucleosomes contain important regulatory regions c. chromatin remodeling activates gene expression d. chromatin remodeling represses gene expressionarrow_forward
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