Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN: 9781305251052
Author: Michael Cummings
Publisher: Cengage Learning
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Chapter 10.7, Problem 1EG
Summary Introduction
To explain: The way in which a single amino acid in beta globin chain can lead to sickle cell anemia.
Introduction: Sickle cell anemia is a genetic disease that is inherited from one generation to next in an autosomal recessive manner. People suffering from this disease show mutations in the genes that code for the β-globin chain of hemoglobin. This results in the formation of improperly folded hemoglobin molecule. Red blood cells of people suffering from this disease are sickle shaped..
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Chapter 10 Solutions
Human Heredity: Principles and Issues (MindTap Course List)
Ch. 10.4 - Prob. 1GRCh. 10.4 - Prob. 2GRCh. 10.7 - Prob. 1EGCh. 10.7 - Prob. 2EGCh. 10 - A couple was referred for genetic counseling...Ch. 10 - A couple was referred for genetic counseling...Ch. 10 - A couple was referred for genetic counseling...Ch. 10 - Many individuals with metabolic diseases are...Ch. 10 - Prob. 2QPCh. 10 - Enzymes have all the following characteristics...
Ch. 10 - Questions 4 through 6 refer to the following...Ch. 10 - Questions 4 through 6 refer to the following...Ch. 10 - Prob. 6QPCh. 10 - Prob. 7QPCh. 10 - Prob. 8QPCh. 10 - a. Compounds A, B, C, and D are known to be...Ch. 10 - b. Compounds A, B, C, and D are known to be...Ch. 10 - a. If an individual who is homozygous for the...Ch. 10 - Prob. 12QPCh. 10 - Suppose that in the formation of phenylalanine...Ch. 10 - If phenylalanine was not an essential amino acid,...Ch. 10 - Phenylketonuria and alkaptonuria are both...Ch. 10 - The normal enzyme required for converting sugars...Ch. 10 - Knowing that individuals who are homozygous for...Ch. 10 - Prob. 18QPCh. 10 - A person was found to have very low levels of...Ch. 10 - If an extra nucleotide is inserted in the first...Ch. 10 - Transcriptional regulators are proteins that bind...Ch. 10 - Prob. 22QPCh. 10 - Prob. 23QP
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- Anemia is characterized by low hemoglobin levels or a reduced number of red blood cells (both of which transport oxygen to cells). A common symptom of anemia is tiredness. a) Explain what the consequences are of anemia on cellular energy production. b) Suggest at least one other cellular effects of anemia and an explanation of this effect.arrow_forwardSickle cell anemia is associated with which of the following: Question 27 options: Sticky patches on the hemoglobin surface only present in the T-state Sticky patches on the hemoglobin surface only present in the R-state A mutant form of hemoglobin called Ɣ-hemoglobin Decreased ability to stabilize the T-state with 2,3-bisphosphoglycerate Decreased ability to bind heme because of the Bohr effectarrow_forwardIn hemoglobin from patients with sickle cell anemia, the hemoglobin ß-chains have a single amino substitution that results in: A) A sticky spot in the hemoglobin causing polymerization O B) A change in the oxygen binding to hemoglobin that causes formation of polymers C) Changes in the interaction between B-chains and x-chains OD) Changes in binding of 2,3-bisphosphoglyceratearrow_forward
- Explain the Types of Mutations in the HBB Gene That Cause β Thalassemia ?arrow_forwardIs there non-functional leukopoiesis in Leukemoid Reaction?arrow_forwardHow does the difference between the-chain and the -chain of hemoglobin explain the differences inoxygen binding between Hb A and Hb F?arrow_forward
- How is hemolytic anemia related to pentose phosphate?arrow_forwardWhat are carrier proteins? Explain its types with examplearrow_forwardAnemia is characterized by low hemoglobin levels or a reduced number of red blood cells (both of which transport oxygen to cells). A common symptom of anemia is tiredness. Please do not copy answers from another website/source. a) Briefly explain what the consequences are of anemia on cellular energy production. b) Suggest at least one other cellular effect of anemia and a brief explanation of this effect.arrow_forward
- Considering that we are all made up of the same 4 nucleotides in our DNA, the same 4 nucleotides in our RNA, and the same 20 amino acids in our proteins, why are we so different from each other? For example, why do some people have sickle cell anemia and others don't?arrow_forwardWhat is oxyhemoglobin? Where does it form?arrow_forwardhow do salt bridges that include amino-terminal carbamate stabilize the deoxy form of hemoglobin. Please answer it asap.... With detailed explanation...arrow_forward
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