Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN: 9781305251052
Author: Michael Cummings
Publisher: Cengage Learning
expand_more
expand_more
format_list_bulleted
Concept explainers
Question
Chapter 10.4, Problem 1GR
Summary Introduction
To explain: Whether the amino acid tyrosine is an essential amino acid in individuals suffering with PKU..
Introduction: Phenylketonuria (PKU) is a genetic disorder that is inherited from one generation into the next. PKU is caused because of the mutation in the gene that codes for the enzyme required for
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solutionStudents have asked these similar questions
Individuals with phenylketonuria cannot convert phenylalanine to tyrosine. Why don’t these individuals exhibit a deficiency of tyrosine?
Vasopressin & oxytocin are hormones produced by the posterior pituitary gland. Both hormones are polypeptides of only 9 amino acids. The sequence of amino acids for vasopressin is: cysteine, tyrosine, phenylalanine, glutamate, asparagine, cysteine, proline, arginine, & glycine. You should have the sequence of amino acid for oxytocin in part II. Referring to your codon chart, explain how one hormone could have been originally derived from small accidental changes that occurred in the genetic code for the other
Which amino acid pair constitutes the hydrophobic patch on sickle cell
hemoglobin that results in formation of protein oligomers with the Glu 6 -->
Val 6 sickle cell mutation? Does normal hemoglobin contain this same amino
acid pair constituting a hydrophobic patch?
Phe 85 / Leu 88; no
Phe 85 / Leu 88; yes
Trp 85 / Leu 88; yes
Olle 85 / Leu 88; yes
Pro 85 / Lys 88; no
Chapter 10 Solutions
Human Heredity: Principles and Issues (MindTap Course List)
Ch. 10.4 - Prob. 1GRCh. 10.4 - Prob. 2GRCh. 10.7 - Prob. 1EGCh. 10.7 - Prob. 2EGCh. 10 - A couple was referred for genetic counseling...Ch. 10 - A couple was referred for genetic counseling...Ch. 10 - A couple was referred for genetic counseling...Ch. 10 - Many individuals with metabolic diseases are...Ch. 10 - Prob. 2QPCh. 10 - Enzymes have all the following characteristics...
Ch. 10 - Questions 4 through 6 refer to the following...Ch. 10 - Questions 4 through 6 refer to the following...Ch. 10 - Prob. 6QPCh. 10 - Prob. 7QPCh. 10 - Prob. 8QPCh. 10 - a. Compounds A, B, C, and D are known to be...Ch. 10 - b. Compounds A, B, C, and D are known to be...Ch. 10 - a. If an individual who is homozygous for the...Ch. 10 - Prob. 12QPCh. 10 - Suppose that in the formation of phenylalanine...Ch. 10 - If phenylalanine was not an essential amino acid,...Ch. 10 - Phenylketonuria and alkaptonuria are both...Ch. 10 - The normal enzyme required for converting sugars...Ch. 10 - Knowing that individuals who are homozygous for...Ch. 10 - Prob. 18QPCh. 10 - A person was found to have very low levels of...Ch. 10 - If an extra nucleotide is inserted in the first...Ch. 10 - Transcriptional regulators are proteins that bind...Ch. 10 - Prob. 22QPCh. 10 - Prob. 23QP
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Two melanocyte-stimulating hormones have the following amino acid sequences. Take a highlighter or colored pencil, and figure out how much of the sequence the porcine MSH has in common with the human MSH (how much is conserved between the two species). beta-MSH (human): Ala-Glu-Lys-Lys-Asp-Glu-Gly-Pro-Tyr-Arg-Met-Glu-His-Phe-Arg-Trp-Gly-Ser-Pro-Pro-Lys-Asp beta-MSH (porcine): Asp-Glu-Gly-Pro-Tyr-Lys-Met-Glu-His-Phe-Arg-Trp-Gly-Ser-Pro-Pro-Lys-Asp One amino acid interrupts the parts you highlighted in each sequence. Which amino acid was it in each and which category does that amino acid belong to on your amino acid chart? this to make much difference for the cross-species function of beta-MSH (why?)? and Do you expectarrow_forwardDraw a peptide for cys-asn- pro-gly (Using the same format in picture)arrow_forwardWhat type of noncovalent interaction occurs between the glutamine and threonine side chains? Draw the structures of these amino acids to show the interaction.arrow_forward
- Insulin possesses two polypeptide chains denoted A and B that are linked by disulfide bonds. Upon denaturation by reduction of the SH groups of insulin, followed by reoxidation, only 7% of the hormone activity is recovered. This is the level of activity expected for random pairing of cysteine residues to form disulfide bonds. How can these data be reconciled with the hypothesis that the amino acid sequence directs protein folding?arrow_forwardCalculate the pI of aspartate amino acids:arrow_forwardWhat are the two essential amino acids in the active site of chymotrypsin?arrow_forward
- Describe the chemical difference between mannose and heptyl alpha-D-mannose. Why does FimH have a higher affinity for heptyl a-D-mannose versus methyl a-D-mannose?arrow_forwardWhat is a glucogenic amino acid? Give three examples.arrow_forwardIf both cysteine residues on the B chain of insulin were changes to alanine residues, how would it affect the quaternary structure of insulin?arrow_forward
- Individuals with phenylketonuria (PKU) are sensitive to phenylalanine in their diet. Why is a warning on foods containing aspartame (L-aspartyl-l-phenylalanine methyl ester) of concern to individuals with PKU?arrow_forwardDescribe the structures of glutamine and alanine. What are the characteristics of the R-groups? What other features of these amino acids make them important as they relate to metabolism?arrow_forwardAn enzyme that catalyzes disulfide– sulfhydryl exchange reactions, called protein disulfide isomerase (PDI), has been isolated. PDI rapidly converts inactive scrambled ribonuclease into enzymatically active ribonuclease. In contrast, insulin is rapidly inactivated by PDI. What does this important observation imply about the relation between the amino acid sequence of insulin and its threedimensional structure?arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning