When a patient exhibits a four-fold or greater rise in antibody titer against a specific microbial antigen between acute-phase and convalescent-phase serum samples, this is considered to be a “seroconversion”. Which of the following would be a correct interpretation of a seroconversion? what option below is the answer? None of the other four answers are a correct interpretation of a seroconversion These results show that the microbe itself has been detected in the patient’s sample(s) These findings cannot be interpreted because antibodies aren’t

When a patient exhibits a four-fold or greater rise in antibody titer against a specific microbial antigen between acute-phase and convalescent-phase serum samples, this is considered to be a “seroconversion”. Which of the following would be a correct interpretation of a seroconversion? what option below is the answer? None of the other four answers are a correct interpretation of a seroconversion These results show that the microbe itself has been detected in the patient’s sample(s) These findings cannot be interpreted because antibodies aren’t

Basic Clinical Laboratory Techniques 6E

6th Edition

ISBN:9781133893943

Author:ESTRIDGE

Publisher:ESTRIDGE

Chapter4: Basic Immunology And Immunohematology

Section4.2: Infectious Mononucleosis Tests

Problem 4RQ

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When a patient exhibits a four-fold or greater rise in antibody titer against a specific microbial antigen between acute-phase and convalescent-phase serum samples, this is considered to be a "seroconversion". Which of the following would be a correct interpretation of a seroconversion? None of the other four answers are a correct interpretation of a seroconversion These findings cannot be interpreted because antibodies aren't specific enough for antigens There is no evidence of current active infection because that would require that the antibody titer is decreasing rather than increasing These results show that the microbe itself has been detected in the patient's sample(s) The results show evidence of current or recent infection by the specific microbe because there has been an active immunologic response to its antigen
a. Seropositivity means having a blood serum that tests positive. Explain why it may or may not develop at the same rate in all patients exposed to the same microbe. b. Would a high rate of false-positives decrease the sensitivity or specificity of a serological test?
Why monoclonal antibodies method is better than polyclonal antibodies method in detecting specific pathogen? Explain the reasons for both selection or rejection methods..
You just received the properly labeled blood bank specimen on patient Aran Stark. You decide to collect some background information about her known historical antibodies before beginning the work-up knowing that she has a history of anti-E, anti-K, anti-Jk^a, anti-Fy^a, anti-M and anti-Le^a. Which antibody can be neutralized? Which antibody is destroyed with 0.2M DTT treatment? Which antibody reactivity is enhanced by acidification? Which of the antibodies that are typically IgG in nature are destroyed by enzymes? Which are enhanced by enzymes? Which of these antibodies have been known to cause hemolytic transfusion reaction? Which of these antibodies are known to react at room temperature? Which of these antibodies react best at 37C? * When you complete the work-up, you note that the anti-Jk^a antibody is no longer detectable. Can the patient receive red blood cells that contain the Jk^a antigen? Why or why not?
A patient is O positive and his serum is agglutinating all screening and panel reagent cells at room temperature. His autocontrol is positive at room temperature also. The patient may have an antibody to a high incidence antigen. One possibility is that he may have a clinically insignificant autoanti-I. How could you prove that the patient has an anti-I antibody?
Why monoclonal antibodies method is better than Polyclonal Antibodies method in detecting specific pathogen. Explain reasons.
At time point A, the patient's IgG titer against antigen X is 1:6, the patient's IgM titer to the same antigen is zero. Later, at time point B, the same patient again encounters antigen X. The IgG titer is zero, and the IgM titer to X is 1:8. Describe a scenario that could explain these data.
If you are working in a diagnostic lab, what will be your choice among Monoclonal or Polyclonal Antibodies method for detection of specific pathogen? Give sufficient justification for selection as well as rejection of any given methods.
Determine the cell of the immune system responsible for processing antigen presented in a patch test.
Serial dilutions are made in order to determine the level of the antibody in the sample. True or False ?
Enzyme immunoassay tests are used to screen blood specimens for the presence of antibodies to HIV, the virus that causes AIDS. Antibodies indicate the presence of the virus. The test is quite accurate but is not always correct. Approximate probabilities of positive and negative test results when the blood tested does and does not actually contain antibodies to HIV are given in the table. Test Result Positive Negative Antibodies present 0.9985 0.0015 Antibodies absent 0.0060 0.9940 Suppose that 1%1% of a large population carries antibodies to HIV in their blood. Probabilities from trials with 2897 people known to be free of HIV antibodies and 673 people known to be infected, reported in J. Richard George, "Alternative specimen sources: methods for confirming positives," 1998 Conference on the Laboratory Science of HIV, found online at the Centers for Disease Control and Prevention, www.cdc.gov. (b) What is the probability that the test is positive for a…
A technologist failed to notice that the centrifuge had not properly centrifuged the test tubes prepared for antibody identification. The time of centrifugation was 15 seconds instead of 30 seconds. What would be the potential error in the interpretation of this test? can please any one provide me ans?