The fibronectin protein has a tripeptide segment with the sequence RGD, which is important in mediating cell-cell interactions. In a healthy environment, the protein is present at pH 7. In many tumors, the extracellular environment is acidified, for example to pH 6. Does the fraction of tripeptides with net neutral charge increase or decrease in tumors relative to healthy tissue? Justify your answer, and quantify this increase or decrease.

The fibronectin protein has a tripeptide segment with the sequence RGD, which is important in mediating cell-cell interactions. In a healthy environment, the protein is present at pH 7. In many tumors, the extracellular environment is acidified, for example to pH 6. Does the fraction of tripeptides with net neutral charge increase or decrease in tumors relative to healthy tissue? Justify your answer, and quantify this increase or decrease.

Biology: The Dynamic Science (MindTap Course List)

4th Edition

ISBN:9781305389892

Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Publisher:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Chapter9: Cell Communication

Section: Chapter Questions

Problem 2ITD

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