Debes et al recently described how aging in humans, mice, nematodes, and other eukaryotes is associated with an increase in the average speed of transcriptional elongation by RNA polymerase II. Overexpression of some proteins that decreased PolII elongation speed extended lifespan in the fly Drosophila. For each of the following proteins, predict whether overexpression of that protein (assuming all other cellular components are normal) would likely reduce transcriptional speed, and briefly justify your answer. a) Mediator proteins b) Histone proteins c) Insulator binding proteins

Debes et al recently described how aging in humans, mice, nematodes, and other eukaryotes is associated with an increase in the average speed of transcriptional elongation by RNA polymerase II. Overexpression of some proteins that decreased PolII elongation speed extended lifespan in the fly Drosophila. For each of the following proteins, predict whether overexpression of that protein (assuming all other cellular components are normal) would likely reduce transcriptional speed, and briefly justify your answer. a) Mediator proteins b) Histone proteins c) Insulator binding proteins

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Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter10: From Proteins To Phenotypes

Section: Chapter Questions

Problem 21QP: Transcriptional regulators are proteins that bind to promoters (the 5-flanking regions of genes) to...

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Choose all that apply regarding gene transcription in eukaryotes: Multiple transcription factors are necessary to form the pre-initiation complex (PIC) of RNA Pol II. The 5' cap of mRNA requires the free triphosphate on the nucleotide at the 5' end. Introns must be removed from the initial RNA transcipt. Histone acetylation is a method controlling gene expression. Acetylation creates more positive charges on histones, leading to tighter binding of the proteins to DNA. Exons are removed from mRNA by the spliceosome. RNA polymerase II must completely finish an mRNA transcript before processing can begin. RNA polymerase I catalyzes the synthesis of the majority of ribosomal RNA. The hormone 173-estradiol binds to a G-protein coupled receptor to control gene transcription.
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