*In the presence of saturating amounts of oxaloacetate, the activityof citrate synthase from pig heart tissue shows a sigmoidal dependenceon the concentration of acetyl-SCOA as shown below.SCOA is added, the curve shifts to the right and becomes even moresigmoidal. On the basis of these observations, explain how succinyl-SCOA regulates the activity of citrate synthase. Why is succinyl-SCOAan appropriate signal for regulation of the citric acid cycle?does the regulation of citrate synthase control the rate of cellularrespiration in pig heart tissue?100 -80 succinyl-CoAActivity (% of V,6040-NoSuccinyl-CoAadded20 40 60 80 100 120[Acetyl-CoAl(pM)-How-

In presence of succinyl Coenzyme A, the sigmoidal curve shifted to the right and becomes even more…

of citrate synthase from pig heart tissue shows a sigmoidal dependenc *In the presence of saturating amounts of oxaloacetate, the act on the concentration of acetyl-SCOA as shown below. sigmoidal. When succinyl- SCOA is added, the curve shifts to the right and becomes even more SCOA regulates the activity of citrate synthase. On the basis of these observations, explain how succinyl- an appropriate signal for regulation of the citric acid cycle? does the regulation of citrate synthase control the rate of cellular Why is succinyl-SCOA How respiration in pig heart tissue? Activity (% of Vmax) 100- No succinyl-CoA J 40 - added 40 60 (Acetyl-CoA) (µM) 80 60 20 20 Succinyl-CoA 100 120 80

of citrate synthase from pig heart tissue shows a sigmoidal dependenc *In the presence of saturating amounts of oxaloacetate, the act on the concentration of acetyl-SCOA as shown below. sigmoidal. When succinyl- SCOA is added, the curve shifts to the right and becomes even more SCOA regulates the activity of citrate synthase. On the basis of these observations, explain how succinyl- an appropriate signal for regulation of the citric acid cycle? does the regulation of citrate synthase control the rate of cellular Why is succinyl-SCOA How respiration in pig heart tissue? Activity (% of Vmax) 100- No succinyl-CoA J 40 - added 40 60 (Acetyl-CoA) (µM) 80 60 20 20 Succinyl-CoA 100 120 80

Chemistry for Today: General, Organic, and Biochemistry

9th Edition

ISBN:9781305960060

Author:Spencer L. Seager, Michael R. Slabaugh, Maren S. Hansen

Publisher:Spencer L. Seager, Michael R. Slabaugh, Maren S. Hansen

Chapter23: Carbohydrate Metabolism

Section: Chapter Questions

Problem 23.70E

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