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Myasthenia Gravis: flaccid paralysis
Explain the physiologic basis of flaccid paralysis in myasthenia gravis.
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- discuss the mechanism of pyridostigmine in treating myasthenia gravisCompare and contrast the functions, anatomy and characteristics of skeletal vs smooth muscle. Characterize the microscopic anatomical structure of skeletal muscle. Describe the organization of the sarcomere. Characterize the actions of motor neurons at the neuromuscular junction. Explain the process by which skeletal muscle contraction occurs. Describe the composition of and the function of cerebrospinal fluid and the blood-brain barrier. Explain the major role of the lobes, areas and regions of the brain. Contrast the effects of the various cranial nerves. Please answer all not gradedIllustrate the features of Myasthenia gravis?
- Compare and contrast the functions, anatomy and characteristics of skeletal vs smooth muscle. Characterize the microscopic anatomical structure of skeletal muscle. Describe the organization of the sarcomere. Characterize the actions of motor neurons at the neuromuscular junction. Explain the process by which skeletal muscle contraction occurs. Describe the composition of and the function of cerebrospinal fluid and the blood-brain barrier. Explain the major role of the lobes, areas and regions of the brain. Contrast the effects of the various cranial nerves. Answer all, not graded, thanksDifferentiate between myopia and hypermetropia.Describe the structures and functions of actin-based motor proteins, myosins.
- A patient is thought to be suffering from either muscular dystrophyor myasthenia gravis. How would you distinguish between the twoconditions?Co-activation of α and γ-motor neurons :-a- increases γ-motor neuron discharge whenever the activity of α-motor neurons rises to a high levelb- is mediated by interneurons that link the α and γ-motor neuronsc- maintains the proprioceptive information to higher centers during muscle contractiond- increases the α-motor neuron discharge whenever the activity of γ-motor neurons rises to a high levelExplain why α‒γ coactivation is important for quality control of voluntary motions.
- Describe a muscle spindle and its function considering the following items. Use all terms in paragraph form to describe: - Extrafusal fibers - Intrafusal fibers - Alpha motor neurons - Gamma motor neurons - Capsule - Contraction - Afferent nerve fiber - Somatic reflex (as in the patellar reflex)Describe the functions of gamma motor neurons and explain why they are stimulated at the same time as alpha motor neurons during voluntary muscle contractions.Muscle spindle structures consist of: Extrafusal muscle fibers and gamma motor neurons Extrafusal muscle fibers and alpha motor neurons Golgi tendon organs and gamma motor neurons Intrafusal muscle fibers and gamma motor neurons