Identify the molecule that best matches each description. Each answer may be used once, more than once, or not at all. Transcription factor held in the cytoplasm in an inactive form in complex with an inhibitor protein and released upon signaling from receptors of innate and adaptive immunity. Pro-inflammatory cytokine made and stored in macrophages as an inactive precursor; excessive production is associated with autoinflammatory diseases. Soluble product of cleavage by C3 convertase, acts to 1. C3a 2. C4 (complement component 4) 3. Complement receptor 2 (CR2) 4. Factor H 5. Toll-like receptor 4 (TLR4) 6. Interleukin-18 (IL-18)

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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associated with
autoinflammatory
diseases.
Soluble product of
cleavage by C3
convertase, acts to
increase inflammation
(anaphylatoxin).
A soluble negative
regulator of complement
activation that can also
become membrane-
associated by binding to
sialic acid.
Extracellular domain
containing leucine-rich
repeat (LRR) regions
recognizes
lipopolysaccharide (LPS) of
Gram-negative bacteria.
4.
Factor H
5. Toll-like receptor 4 (TLR4)
6. Interleukin-1B (IL-1B)
7. Nuclear factor KB (NFKB)
8. Type I interferon
9. Autoimmune regulator (AIRE)
10. Interleukin-10 (IL-10)
Transcribed Image Text:associated with autoinflammatory diseases. Soluble product of cleavage by C3 convertase, acts to increase inflammation (anaphylatoxin). A soluble negative regulator of complement activation that can also become membrane- associated by binding to sialic acid. Extracellular domain containing leucine-rich repeat (LRR) regions recognizes lipopolysaccharide (LPS) of Gram-negative bacteria. 4. Factor H 5. Toll-like receptor 4 (TLR4) 6. Interleukin-1B (IL-1B) 7. Nuclear factor KB (NFKB) 8. Type I interferon 9. Autoimmune regulator (AIRE) 10. Interleukin-10 (IL-10)
Identify the molecule that best matches each description. Each answer may be used
once, more than once, or not at all.
Transcription factor held in
the cytoplasm in an
inactive form in complex
with an inhibitor protein
and released upon
signaling from receptors of
innate and adaptive
immunity.
Pro-inflammatory cytokine
made and stored in
macrophages as an
inactive precursor;
excessive production is
associated with
autoinflammatory
diseases.
Soluble product of
cleavage by C3
convertase, acts to
1. C3a
2. C4 (complement component 4)
3. Complement receptor 2 (CR2)
4. Factor H
5.
6. Interleukin-1B (IL-1B)
Toll-like receptor 4 (TLR4)
Transcribed Image Text:Identify the molecule that best matches each description. Each answer may be used once, more than once, or not at all. Transcription factor held in the cytoplasm in an inactive form in complex with an inhibitor protein and released upon signaling from receptors of innate and adaptive immunity. Pro-inflammatory cytokine made and stored in macrophages as an inactive precursor; excessive production is associated with autoinflammatory diseases. Soluble product of cleavage by C3 convertase, acts to 1. C3a 2. C4 (complement component 4) 3. Complement receptor 2 (CR2) 4. Factor H 5. 6. Interleukin-1B (IL-1B) Toll-like receptor 4 (TLR4)
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