5) When the number of spare receptor is much more than the amount of irreversibleantagonist X, what will happen to the agonist Y when it is co-administrated with X? a.There will be a downward shift of log dose response curveb. There will be a upward shift of log dose response curvec. There will be a right shift of log dose response curved. There will be a left shift of log dose response curvee. There will be no change for log dose response curve6) The maximum plasma concentration of a drug is reached when a.The elimination rate equals the absorption rate b. The eliminationrate is very highc. The elimination rate is lower than the absorption rated. The elimination rate is minimume. The absorption far exceeds the elimination rate7) Most drug receptors a a.Carbohydrateb. Phospholipidsc. Steroidsd. Proteinse. Enzymes

As irreversible antagonist X is added. It will decrease the number of receptors that are available…

Answered: 5) When the number of spare receptor is…

Essentials of Pharmacology for Health Professions

7th Edition

ISBN:9781305441620

Author:WOODROW

Publisher:WOODROW

Chapter21: Musculoskeletal And Anti-inflammatory Drugs

Section: Chapter Questions

Problem 18CRQ

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5) When the number of spare receptor is much more than the amount of irreversible antagonist X, what will happen to the agonist Y when it is co-administrated with X? a. There will be a downward shift of log dose response curve b. There will be a upward shift of log dose response curve c. There will be a right shift of log dose response curve d. There will be a left shift of log dose response curve e. There will be no change for log dose response curve
1. Which of the following drugs is not a cardioselective beta-blocker? *A. EsmololB. AtenololC. PropranololD. MetoprololE. Bisoprolol 2. It is the ability of a drug to initiate cellular effects.A. AgonistB. AntagonistC. EfficacyD. Intrinsic Activity 3. What type of antagonism is exemplified when the interaction of two (2) drugs whoseopposing actions in the body tend to cancel each other’s effect?A. Physiological antagonismB. Pharmacokinetic antagonismC. Chemical antagonismD. Non-competitive antagonismE. Pharmacological antagonism 4. Which enzyme breaks down the neurotransmitter of the parasympathetic nerve?A. Catechol-O-Methyl TransferaseB. AcetylcholinesteraseC. Monoamine OxidaseD. DecarboxylaseE. CYP isozymes 5. Which drug exhibits similar mechanism of action with Reserpine? *A. VesamicolB. PilocarpineC. Botulinum toxinD. EpinephrineE. Neostigmine 6. Which of the following drugs is not a muscarinic-receptor antagonist used tocounteract cholinergic transmission? *A. UrecholineB.…
There are several drugs that can interact with each other when given together. What happens when a patient is given phenylbutazone at the same time as warfarin is...A. is bleeding profuselyB. the presence of phenylbutazone . metabolizing enzyme inductionC. Warfarin's anticoagulant activity is decreasedD. an increase in anti-inflammatory effectE. Induction of warfarin metabolizing enzymes Eugenol has activity as an antibacterial. The group responsible for this activity is….A. benzeneB. cyclicC. sulfonamidesD. phenolE. sulfa Which statement is true regarding drugs given intramuscularly?A. The drug goes directly to the network depotB. all answers are correctC. The drug undergoes an absorption phase until it reaches the blood circulationD. the drug passes through the bloodstream in the processE. The drug is absorbed from the gastrointestinal tract
Which direction would a competitive reversible antagonist (plus agonist) shift the dose-response curve of the agonist? Group of answer choices A.To the left B.To the right C.Down D.Up E.To the right and possibly down
1. Researchers incubated J3’s in the absence of Unknown Factor X. Upon the addition of a membrane-permeant cGMP agonist (a cGMP agonist able to penetrate into the J3’s) you would expect to see STIMULATION/INHIBITION (highlight one) of the J3 activation pathway.2. Researchers incubated J3’s in the presence of Unknown Factor X, but with the addition of a membrane-permeant CYP antagonist. In this case, you would expect to see STIMULATION/INHIBITION (highlight one) of the J3 activation pathway.
You have determined the mode of inhibition for NSAMB but you must now determine the KI value to obtain a relative measure of the potency of this inhibitor. Based on the mode of inhibition, how are the equations for KP and V influenced by the presence of inhibitor? rapp Vmas K is unaffected by changes in [I]; VpP max 1+ KM Vapp max 1+ 1+ KI KPP Км (1+ ) Vapp max = M K1 1+ Neither KPP nor VPP app max are affected by changes in I O KP = KM(1+ *): V is unaffected by changes in [I] app M
Label the following on the graph: 100 100 1000 10000 Dose Partial agonist Choose... Antagonist Choose... C Agonist Percent Effect
Denervation supersensitivityof the muscle in LMN lesions is due to : -a- increased release of neurotransmitter from the degenerating nerve terminalsb- decreased release of neurotransmitter from the degenerating nerve terminalsc- increased number of transmitter receptors in fibers of the denervated muscled- decreased number of transmitter receptors in fibers of the denervated muscle
Which of the following statements is true? L Ceftriaxone can't pass across the blood brain barrier in any conditions II. 2nd generation cephalosporins are not recommended in the treatment of pseudomonal infections III. Most common adverse effect of cephalosporins is hypersensitivity reactions IV. High dose-long term ceftriaxone use suppresses the action of warfarin Select one: a.I and IV bill and Ill c.I, II and III d.I and III ell, III and IV Clear my choice
Exposure to the compound below is most effectively treated with? CI CI N do= O-P O CH3 CH3 Itranscript O A. atropine & trimethaphan O B. edrophonium and methacholine OC. atropine & pralidoxime O D. pilocarpine & pralidoxime O E. neostigmine OF. IV bolus of acetylcholine
Which cell concentration can yield detectable TNF-a in the stimulation experiment O a. 10 cells/mL O b. 1000 cells/mL Oc. 1 cell/mL d. 100,000 cells/mL
All of the following augment activity of biguanides, except:A. MAO inhibitorsB. ACE inhibitorsC. Beta blockersD. Delayed calcium channel blockersE. Тetracyclines

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