Ali is a 75-year-old, 62-kg (5 ft 9 in) male with S. epidermidis sepsis. Hiscurrent serum creatinine is 1.3 mg/dL, and it has been stable sinceadmission. Compute a vancomycin dose for this patient to provide asteady-state peak concentration of 40 µg/mL and a steady-state troughconcentration of 15 µg/mL.a. Estimate creatinine clearance (CI)b. Estimate volume of distribution (Vd)c. Estimate rate constant (Ke) and half-life (t1/2)d. Calculate the dose intervale. Using IV bolus equations, calculate the dosef. Calculate the loading dose, if needed for this patientAssume that Ali (same patient in question 1) wasprescribed vancomycin 1000 mg every 36 hours. After few days,Steady-state vancomycin concentrations were obtained before and afterthe fourth dose, and the peak concentration (obtained ½ hour after a 1-hour infusion of vancomycin) was 34 µg/mL while the troughconcentration (obtained immediately before dosage administration) was2.5 pg/mL. Compute a revised vancomycin dose for this patient toprovide a steady-state peak concentration of 48 ug/mL and a steady-state trough concentration of 17 ug/mL.a. Estimate new rate constant (Ke) and half-life (t1/2)b. Estimate volume of distribution (Vd) using this equation Cmaxss=+ Cminssc. Calculate the new dose intervalDvdd. Calculate the new dose

Given- Serum creatinine- 1.3mg/dl Steady peak concentration-40ug/ml Steady state trough…

Answered: Ali is a 75-year-old, 62-kg (5 ft 9 in)…

Curren'S Math For Meds: Dosages & Sol

11th Edition

ISBN:9781305143531

Author:CURREN

Publisher:CURREN

Chapter15: Adult And Pediatric Dosages Based On Body Weight

Section: Chapter Questions

Problem 31SST

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