2 nm DNA double helix Linker Wrapping of DNA around histone (H1) a histone octamer 60 nm 11 nm Histone Nucleosome octamer (a) Nucleosomes ("beads on a string") 33 nm Formation of a three-dimensional zigzag or solenoid structure via histone H1 and nonhistone proteins 30 nm 200 nm (b) 30-nm fiber Anchoring of the 30-nm fiber to protein filaments to form radial loop domains (b) 30-nm fiber Anchoring of the 30-nm fiber to protein filaments to form radial loop domains 300 nm (c) Radial loop domains Protein filament Additional folding in which the radial loops are closely compacted. In a metaphase chromosome, the protein filaments form a scaffold that gives a chromosome its shape. pellnae 700 nm 180 nm Protein scaffold 1400 nm (d) Metaphase chromosome 640 nm

2 nm DNA double helix Linker Wrapping of DNA around histone (H1) a histone octamer 60 nm 11 nm Histone Nucleosome octamer (a) Nucleosomes ("beads on a string") 33 nm Formation of a three-dimensional zigzag or solenoid structure via histone H1 and nonhistone proteins 30 nm 200 nm (b) 30-nm fiber Anchoring of the 30-nm fiber to protein filaments to form radial loop domains (b) 30-nm fiber Anchoring of the 30-nm fiber to protein filaments to form radial loop domains 300 nm (c) Radial loop domains Protein filament Additional folding in which the radial loops are closely compacted. In a metaphase chromosome, the protein filaments form a scaffold that gives a chromosome its shape. pellnae 700 nm 180 nm Protein scaffold 1400 nm (d) Metaphase chromosome 640 nm

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter29: Transcription And The Regulation Of Gene Expression

Section: Chapter Questions

Problem 5P

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5’-GGC TAC GTA ACT TGA TAA-3’ (a) mRNA codons that are transcribed from the DNA (b) tRNA anticodons for each of the mRNA codons (c) The sequence of amino acids in the resulting polypeptide. (d) Provide the sequence of another possible DNA strand that will lead to synthesis ofthe same polypeptide.
34. What is the empirical formula of the histone composition in a nucleosome? A) 2 (H1+ H2A + H2B + H3 + H4) B) H1 H2A + H2B + H3 + H4 2*(H2A + H2B+H3 + H4) + H1 None of the above D) H N=C N-HO CIN
A diploid human cell contains approximately 6.4 billion base pairs of DNA. Q. How many nucleosomes are present in such a cell? (Assume that the linker DNA encompasses 40 bp.)
29.) equalities now called Chargaff's rule. Biochemist Erwin Chargaff was the first to note that, in DNA, [A]=[T] and [G]=[C], A) Using this rule, determine the percentages of all the bases in DNA that is 20% thymine. [A] = [C] = [G] [T] = 20% %3D - B) If a single strand of RNA is 20% uracil, what can you predict about the percentages of the remaining bases and why?
2.1 Given the following eukaryotic DNA strand, transcribe and translate the DNA into apolypeptide using the 3’ – 5’ strand as the template. You may use drawings, diagrams,colours and annotations to describe how the DNA strand will be synthesized into afunctional protein. 5’ - TATAAAAASSMSBMDATGSBDCCMBDBAATBSMDSTGTGTCCTMSBAG – 3’ (KEY: The letters SBMD are “made up” nucleic acids that depict non-coding regions in theDNA, hypothetically S pairs with B and M pairs with D).
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Pissssssssss helppppppppp, One strand of DNA reads T-A-C-G-A-G-C-T-C. Describe the steps of protein synthesis of a eukaryotic cell using the nitrogen bases of the given DNA strand. Include the following terms in your description (1 paragraph pls): -DNA - mRNA -protein -tRNA -Amino acid -codon -nucleus -Ribosome -cytoplasm -transcription -translation
Number of Okazaki Fragments in E. coli and Human DNA Replication Approximately how many Okazaki fragments are synthesized in the course of replicating an E. coli chromosome? How many in replicating an â€œaverageâ€� human chromosome?
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Cell (A) contains 3.1 billion (3.1 x 109) base pairs of DNA. Each nucleosome has about 200 bp of DNAwrapped around the histone core.a. What is the maximum number of nucleosomes that can be present in the cell?b. What is the maximum number of H2A histone protein molecules that can be present in the cell?
Eukaryotic Genetic Sequence: 5'-TAC CAT GAT CCC TAT - 3' 1. What would be the newly synthesized DNA strand and explain how the strand will be replicated. Where in the cell would this occur? 2. What would be the synthesized mRNA strand, and how is it transcribed from the original DNA strand, and then converted from a pre-mRNA strand to a mature mRNA? Where in the cell does this occur? 3. What would be the anti-codons for the tRNA. What are the amino acids generated based on the RNA. How are these amino acids translated into protein and where in the cell does this happen?
Description about nucleosome what general type of interaction is(are) largely responsible for the protein-dna associations in a nuclosome? explain