Concepts of Genetics (11th Edition)
11th Edition
ISBN: 9780321948915
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino
Publisher: PEARSON
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Chapter 4, Problem 2PDQ
CONCEPT QUESTION
Review the Chapter Concepts list on p. 62. These all relate to exceptions to the inheritance patterns encountered by Mendel. Write a short essay that explains why multiple and lethal alleles often result in a modification of the classic Mendelian monohybrid and dihybrid ratios.
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Students have asked these similar questions
Discuss how Mendel’s monohybrid results served as the basis for all but one of his postulates. Which postulate was not based on these results? Why?
Provide a proof that a different phenotype can be produced from the same genotype. What are the possible causes for this different expression?
How can the different gene interactions be differentiated from each other and from the Mendelian inheritance?
58
A family has two children with an undiagnosed, very rare neurodevelopmental condition illustrated in the pedigree
below. Neither parent is affected and there is no family history of this disorder.
The following two questions relate to this pedigree.
What is the most likely mode of inheritance for this condition?
Select one alternative:
Dominant
O It is not inherited
Recessive
X-linked recessive
Chapter 4 Solutions
Concepts of Genetics (11th Edition)
Ch. 4 - In the guinea pig, one locus involved in the...Ch. 4 - In some plants a red flower pigment, cyanidin, is...Ch. 4 - Below are three pedigrees. For each trait,...Ch. 4 - Prob. 1CSCh. 4 - Prob. 2CSCh. 4 - Prob. 3CSCh. 4 - HOW DO WE KNOW? In this chapter, we focused on...Ch. 4 - CONCEPT QUESTION Review the Chapter Concepts list...Ch. 4 - In shorthorn cattle, coat color may be red, white,...Ch. 4 - In foxes, two alleles of a single gene, P and p,...
Ch. 4 - In mice, a short-tailed mutant was discovered....Ch. 4 - List all possible genotypes for the A, B, AB, and...Ch. 4 - With regard to the ABO blood types in humans,...Ch. 4 - In a disputed parentage case, the child is blood...Ch. 4 - The A and B antigens in humans may be found in...Ch. 4 - In chickens, a condition referred to as creeper...Ch. 4 - In rabbits, a series of multiple alleles controls...Ch. 4 - Three gene pairs located on separate autosomes...Ch. 4 - As in Problem 12, flower color may be red, white,...Ch. 4 - Horses can be cremello (a light cream color),...Ch. 4 - With reference to the eye color phenotypes...Ch. 4 - Pigment in mouse fur is only produced when the C...Ch. 4 - In rats, the following genotypes of two...Ch. 4 - Given the inheritance pattern of coat color in...Ch. 4 - In a species of the cat family, eye color can be...Ch. 4 - In a plant, a tall variety was crossed with a...Ch. 4 - In a unique species of plants, flowers may be...Ch. 4 - Five human matings (15), identified by both...Ch. 4 - A husband and wife have normal vision, although...Ch. 4 - In humans, the ABO blood type is under the control...Ch. 4 - In Drosophila, an X-linked recessive mutation,...Ch. 4 - Another recessive mutation in Drosophila, ebony...Ch. 4 - In Drosophila, the X-linked recessive mutation...Ch. 4 - While vermilion is X-linked in Drosophila and...Ch. 4 - In a cross in Drosophila involving the X-linked...Ch. 4 - Consider the three pedigrees below, all involving...Ch. 4 - In goats, the development of the beard is due to a...Ch. 4 - Predict the F1 and F2 results of crossing a male...Ch. 4 - Two mothers give birth to sons at the same time at...Ch. 4 - Discuss the topic of phenotypic expression and the...Ch. 4 - Prob. 35PDQCh. 4 - Labrador retrievers may be black, brown...Ch. 4 - A true-breeding purple-leafed plant isolated from...Ch. 4 - In Dexter and Kerry cattle, animals may be polled...Ch. 4 - A geneticist from an alien planet that prohibits...Ch. 4 - The following pedigree is characteristic of an...Ch. 4 - Students taking a genetics exam were expected to...Ch. 4 - In four oclock plants, many flower colors are...Ch. 4 - Proto-oncogenes stimulate cells to progress...Ch. 4 - Below is a partial pedigree of hemophilia in the...
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- A. What is the inheritance pattern of the pedigree illustrated above? Explain in 1 sentence minimum citing two pieces of evidence from the pedigree to support your answer. B. Assuming that the disorder portrayed in this pedigree is very rare, based on your answer in a., what are the most likely genotypes of I-2, Ill-7 and I1-3. C. Based on your answer in a, what are the odds that IV-1 and IV-2 would have an affected male child?arrow_forwardMany genetic disorders exhibit locus heterogeneity. Define andgive two examples of locus heterogeneity. How does locus heterogeneityconfound a pedigree analysis?arrow_forwardDiscuss why Mendel's hybrid offspring begin to exhibit the original traits expressed by the P1 generation or the pure-breeding parents used in the original cross. What would happen if the hybrid offspring were allowed to breed without interference from Mendel for an extended period of time and the different ways plants can breed.arrow_forward
- Answer the following questions given the pedigree below. Please assume that no other mutations are occurring, complete penetrance, and that the individual marked with an asterisk (*) doesn’t carry the allele causing the affected phenotype. Q4) Assuming II-2 and II-3 want to have another child. what are all the possible genotypes, and what is the percentage that their child will be affected?arrow_forward3:48 1 Drive Multiple genes or polygenic inheritance: An additive effect of two or more genes on a single phenotypic character. 16. Skin color appears to be controlled by several genes. This creates a continuum of variation) also seen in height, hair color, etc.) If this polygenic explanation of the inheritance of human skin pigmentation is correct, how do the skin colors of the following four individuals compare? Which of the couples could have children with the widest range of skin colors? Why? Couple 1: aaBbCC and aaBbCC Couple 2: AaBbCc and AaBbCc Lethal Genes: An allele that if present, results in premature death. Lethal genes can be either dominant (heterozygotes or homozygous dominant will be affected) or recessive (only homozygous recessive will die). 17. When Mexican Hairless dogs are crossed with normal-haired dogs, about half of the puppies are normal (have hair) and half are hairless. When two Mexican hairless dogs are crossed, about 1/2 of the puppies are hairless, 1/4…arrow_forwardHelp me create a pedigree of this information: Pedigree analysis: Generation 1: Normal parents (AA x AA) Generation 2: Carrier parents (AA x AS) Generation 3: Affected child (AS x AS) Generation 4: Affected grandchild (SS) This pedigree has two normal parents in the first generation. Second generation carriers carry the sickle cell trait from one parent. The disease is 25% more likely to be inherited in the third generation if both parents have the 'S' allele. If both parents have the 'S' allele, their children will have sickle cell anemia in the fourth generationarrow_forward
- Which of the following statements is true about the molecular basis of Mendel's second law? OThe random attachment of the sister chromatids and the split of them into different daughter cells during the second round of cell division in Meiosis ensure Mendel's second law of independent assortment of alleles. OThe random attachment of the sister chromatids and the split of them into different daughter cells during the first round of cell division in Meiosis ensure Mendel's 2nd law. O The molecular basis of independent assortment of alleles is the segregation of sister chromatids during the second round of cell division in Meiosis. O The molecular basis of independent assortment of alleles is the segregation of homologous chromosomes during the second round of cell division in Meiosis. O The molecular basis of independent assortment of alleles is the segregation of homologous chromosomes during the first round of cell division in Meiosis.arrow_forwardConsider a situation where you have a parental cross with the mother and father phenotypes listed below. Remember that the genotype for the wild-type parent is always homozygous. The counts of the F1offspring are listed in Table 1. Two randomly selected individuals are selected and mated to produce a set of F2individuals. If you test the F2counts to determine whether they are consistent with an autosomal dominant mode of inheritance, what is your decision? Use a 0.05 significance level. PARENTAL CROSS Parental cross: Mother with disease phenotype, Father with wild-type phenotype. Table 1. F1 DATA Gender Phenotype Disease Wild-type Male 0 23 Female 0 34 Table 2. F2 DATA Gender Phenotype Disease Wild-type Male 7 25 Female 0 25 A. Do not reject the null hypothesis that the F2 data are consistent with an autosomal dominant mode of inheritance; chi-square goodness of fit test p-value is greater than 0.05. B. Reject the null hypothesis that the F2…arrow_forwardThis pedigree traces the inheritance of a rare disease in humans. a. Based on this pedigree, is the allele for this disease dominant or recessive? Explain. b. What genotypes are possible for the individuals labeled 1, 2, and 3?arrow_forward
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