Nester's Microbiology: A Human Perspective
Nester's Microbiology: A Human Perspective
9th Edition
ISBN: 9781259709999
Author: Denise G. Anderson Lecturer, Sarah Salm, Deborah Allen
Publisher: McGraw-Hill Education
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Chapter 3, Problem 6SA

Give two reasons why the outer membrane of Gram-negative bacteria is medically significant.

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Gram-negative bacteria are surrounded by two membrane bilayers separated by a space termed the periplasm. The periplasm is a multipurpose compartment separate from the cytoplasm. The periplasm has a distinct oxidizing environment that allow certain key protein structural features to be formed. Can you identify an amino acid(s) that would be affected by this oxidizing environment? How would it be affected, and what structural features would be sensitive to this environment? Can you discuss the implications of this from a standpoint of recombinant protein expression?
One major difference in the envelope structure between gram positive bacteria and gram-negative bacteria is the presence or absence of a cytoplasmic membrane. True or false?
Why might clinical medicine have an interest in understanding bacterial cell division at the molecular level? Explain why a hyperthermophile would probably not be a human pathogen. Describe four factors that may have an influence on the effectiveness of an antimicrobial treatment. Explain why 70% or 80% alcohol is more effective than 100% alcohol in controlling microorganisms.
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