Essentials of Genetics (9th Edition) - Standalone book
9th Edition
ISBN: 9780134047799
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino
Publisher: PEARSON
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Textbook Question
Chapter 21, Problem 2PDQ
Review the Chapter Concepts list on page 422. These all center on quantitative inheritance and the study and analysis of polygenic traits. Write a short essay that discusses the difference between the more traditional Mendelian and Neomendelian modes of inheritance (qualitative inheritance) and quantitative inheritance.
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Match each of the following examples to the appropriate type of non-Mendelian inheritance.
1. A homozygous recessive genotype for the gene that encodes phenylalanine hydroxylase
(which breaks down the amino acid phenylalanine) causes lighter skin color, a musty
odor, differences in intellectual development, and seizures.
2. In pea plants, alleles of Gene W control flower color, with the dominant allele (W)
leading to purple flower.color, and the recessive allele (w) leading to white flower color.
Usually, a genotype of WW or Ww leads to purple flowers. However, when Gene C is
homozygous recessive, WW or Ww plants always have white flowers.
3. In mallard ducks, feather coloring is controlled by Gene F. A dominant allele (F) leads to
green head feathers, while a recessive allele (f) leads to brown head feathers. In male
mallards, inheritance of one or more F alleles always leads to the green head feather
trait. But female mallards always have brown head feathers,…
Chapter 21 Solutions
Essentials of Genetics (9th Edition) - Standalone book
Ch. 21 -
CASE STUDY | A genetic flip of the coin
On July...Ch. 21 - CASE STUDY|A genetic flip of the coin On July 11,...Ch. 21 -
CASE STUDY|A genetic flip of the coin
On July...Ch. 21 - HOW DO WE KNOW?
1. In this chapter, we focused on...Ch. 21 - Review the Chapter Concepts list on page 422....Ch. 21 -
3. Define the following: (a) polygenic, (b)...Ch. 21 - A dark-red strain and a white strain of wheat are...Ch. 21 - Height in humans depends on the additive action of...Ch. 21 -
6. An inbred strain of plants has a mean height...Ch. 21 - Prob. 7PDQ
Ch. 21 - In the following table, average differences of...Ch. 21 - What kind of heritability estimates (broad sense...Ch. 21 - List as many human traits as you can that are...Ch. 21 - Corn plants from a test plot are measured, and the...Ch. 21 -
12. The following variances were calculated for...Ch. 21 - The mean and variance of plant height of two...Ch. 21 - A hypothetical study investigated the vitamin A...Ch. 21 - In a herd of dairy cows the narrow-sense...Ch. 21 - In an assessment of learning in Drosophila, flies...Ch. 21 - Suppose you want to develop a population of...Ch. 21 -
18. In a population of tomato plants, mean fruit...Ch. 21 - In a population of 100 inbred, genotypically...Ch. 21 - In a cross between a strain of large guinea pigs...Ch. 21 - While most quantitative traits display continuous...
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- Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you want to know the results of the cancer, heart disease, and TSD tests if you were Sarah and Adam? Is it their responsibility as potential parents to gather this type of information before they decide to have a child?arrow_forwardPedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. If Sarah carries the mutant cancer allele and Adam carries the mutant heart disease allele, what is the chance that they would have a child who is free of both diseases? Are these good odds?arrow_forwardA pedigree analysis was performed on the family of a man with schizophrenia. Based on the known concordance statistics, would his MZ twin be at high risk for the disease? Would the twins risk decrease if he were raised in an environment different from that of his schizophrenic brother?arrow_forward
- Match the non-Mendelian genetic terms with their descriptor. Genetic and environmental factors collectively influence a phenotypic expression 1. Pleiotropy Two or more genes have a cumulative effect on a 2. Epitasis single phenotype 3. Polygenic Inheritance A single gene has more than one phenotypic effect 4. Multifactorial Effect A gene at one locus has an effect on a gene at another locusarrow_forwardA biotechnology company offers a direct-to-consumer test called the Carrier Status report that generates various calculations about an individual’s genetic risk for certain diseases. Write one paragraph that addresses the following two issues: Why would this be most useful for disorders following an autosomal recessive pattern of inheritance? Provide evidence from your textbook (e.g., Section 10.7, Inheritance Patterns in Humans). Explain how this information might be useful for people during their reproductive years.arrow_forwardPlease consider the following pedigree. Assume that people who marry in to the family do not carry the allele. Assume complete penetrance. I II III 3 IV 1 2 a. Is it possible for the inheritance pattern for the trait illustrated in this pedigree to be as a result of each of the following? Answer yes or no. (i) an autosomal recessive allele (AR) (ii) an autosomal dominant allele (AD) (iii) a X-linked recessive allele (XR) (iv) a X-linked dominant allele (XD) b. Based strictly on the characteristic patterns of inheritance that define the four different options in (a), give a definitive motivation for the most likely mode of inhertance.arrow_forward
- Please consider the following pedigree. Assume that people who marry in to the family do not carry the allele unless otherwise indicated. Assume complete penetrance. I II 5 6 III 6 IV 1 2 a. Is it possible for the inheritance pattern for the trait illustrated in this pedigree to be as a result of each of the following? Answer yes or no. (i) an autosomal recessive allele (AR) (ii) an autosomal dominant allele (AD) (iii) a X-linked recessive allele (XR) (iv) a X-linked dominant allele (XD) b. Provide a genotype for individual III-6 for the most likely mode of inheritance as determined in (a).arrow_forwardMatch the pattern of inheritance to the appropriate term. Group of answer choices 1. Recessive epistasis 2. Frequency-dependent selection 3. Incomplete Dominance 4. Pleiotropy 5. Cytoplasmic inheritance 6. Partial penetrance 7. environmentally dependent phenotype 8. sex influenced trait A. Heterozygotes with different alleles of the DTL1 gene survive better than homozygotes B. The disease is usually passed from a mother to all children C. Pure-breeding pumpkin plants grown on sandy soil have bigger seeds than plants of the same pure-breeding lineage grown on peaty soil. D. A cross between a true-breeding plant with serrated leaf edges and a true- breeding plant with smooth leaf edges produces an F1 generation with 88% plants with serrated leaves. E. A cross between two heterozygotes, DdFf, produces offspring in three phenotypic groups; Long wings in offspring with genotype D_F_, short wings in offspring with D_ff, and no wings in offspring with the genotypes…arrow_forwardConsider two genes. The first one is autosomal with dominant allele A and recessive allele a in the population. The second gene is on the X chromosome with dominant allele R and recessive allele r. Recall that the male Y chromosome has no gene alleles. Match the mode of inheritance (MOI) with the sentence that best describes it.arrow_forward
- Consider two genes. The first one is autosomal with dominant allele A and recessive allele a in the population.The second gene is on the X chromosome with dominant allele R and recessive allele r. Recall that the male Y chromosome has no gene alleles.Match the mode of inheritance (MOI) with the sentence that best describes it.arrow_forwardConsider the following pedigree. Solid symbols represent individuals affected by the trait. Assume complete penetrance and non-variable expressivity. II 3 4 III 1 2 3 5 6 a) what is the mode of inheritance of this trait? b) Does the ratio of affected to unaffected offspring in generation III-1 to 1II-4 match the expected ratio for this mode of inheritance? Explain your answer in terms of the expected ratio versus the ratio observed. Give a reason for your answer. No mark is assigned for yes or no)arrow_forwardGaucher disease is an early onset rare autosomal recessively inherited lysosomal storage disorder (LSD). An adult woman who has no symptoms but has two affected brothers is referred for genetic counselling. Which of the following is correct? Oa. Before any carrier testing is carried out the woman can be correctly informed that the probability that her first son will be affected is 1 in 4. b. With two affected brothers the probability of her being a carrier is 1. Oc. If she is a carrier then the probability that each of her sons and each of her daughters will be affected is 1 in 4. d. The probability that she is a carrier is 1/2 Oe. The probability that she is a carrier is 2/3.arrow_forward
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