Organic Chemistry
Organic Chemistry
6th Edition
ISBN: 9781936221349
Author: Marc Loudon, Jim Parise
Publisher: W. H. Freeman
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Chapter 20, Problem 20.42AP
Interpretation Introduction

Interpretation:

The method of ester synthesis by which methyl benzoate contains as much 18O label oxygen atoms is to be stated.

Concept introduction:

Diazomethane is an explosive compound having molecular formula :CH2N2+. The reaction of carboxylic acids with diazomethane gives methyl esters as the final product. This reaction is commonly termed as Wolff rearrangement.

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Q.2). How will you compare briefly the reactivity of Pyridine and 2-methoxy Pyridine with Furan also explain which one is more reactive toward electrophilic and nucleophilic substitution rxns? Q3). Outline a possible synthetic route for the preparation of a sulfa drug (sulfa pyridine) from benzene.
Explain the differences in acidity between p-cyanobenzoic acid and m-cyanobenzoic acid. Illustrate your answer appropriately, showing the acid-base reaction that takes place with each of these and explaining in such terms as electronic (inductive or resonance) and/or steric effects.
How would you account for the following :(a) Electrophilic susbstitution in case of aromatic amines takes place more readily than benzene.(b) Ethanamide is a weaker base than ethanamine.
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