Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN: 9781305251052
Author: Michael Cummings
Publisher: Cengage Learning
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Chapter 16, Problem 9QP
Cystic fibrosis is an autosomal disease that mainly affects the white population, and 1 in 20 whites are heterozygotes. Genetic testing can diagnose heterozygotes. Should a genetic screening program for cystic fibrosis be instituted? Should the federal government fund it? Should the program be voluntary or mandatory, and why?
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Cystic Fibrosis (CF) is an autosomal recessive condition. Therefore, heterozygous (Cc) carriers do not display symptoms. Two parents who are carriers plan to start a family and you are a genetic counselor helping to advise them about their chances of having children affected by CF.
a) Suppose the couple has 4 children, each one year apart. What is the probability that all 4 children will inherit CF?
b) What is the probability that any 3 of their 4 children will not inherit CF, but 1 will be affected?
c) What is the probability that their first child will not inherit CF, but the younger 3 children will inherit CF?
Huntington's disease is an inherited autosomal dominant disorder that can affect both men and women. Imagine a couple has had
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unaffected, hh.
What is the percent probability that the first child of this couple will have Huntington's disease?
probability:
%
What is the percent probability that two of the seven children will have Huntington's disease?
probability:
%
Below is a pedigree chart for a family that has a history of Alkaptonuria. Individuals infected with this condition can have darkened skin, brown urine, and can suffer from joint damage and other complications. Given this pedigree answer the following questions.
Given the data in the pedigree chart is this genetic condition autosomal dominant or autosomal recessive?
What are the genotypes for #1, #2, and #3?
If either of the 4th generation "aa" females were to mate with a homozygous dominant male would any of their offspring illustrate the phenotype? Why or why not?
Chapter 16 Solutions
Human Heredity: Principles and Issues (MindTap Course List)
Ch. 16.5 - Should fertility clinics be required to disclose...Ch. 16.5 - Prob. 2EGCh. 16 - Would ISCI be an option? Why or why not? Jan, a...Ch. 16 - Jan is concerned about using ART. She wants to be...Ch. 16 - List the common infertility problems in women....Ch. 16 - Prob. 2QPCh. 16 - Prob. 3QPCh. 16 - What is the difference between gamete...Ch. 16 - Why should women consider collecting and freezing...Ch. 16 - Prob. 6QP
Ch. 16 - Researchers are learning how to transfer...Ch. 16 - Prob. 8QPCh. 16 - Cystic fibrosis is an autosomal disease that...Ch. 16 - Prob. 10QPCh. 16 - Gene therapy involves: a. the introduction of...Ch. 16 - In selecting target cells to receive a transferred...Ch. 16 - The prospect of using gene therapy to alleviate...Ch. 16 - Is gene transfer a form of eugenics? Is it...Ch. 16 - A couple who wishes to have children visits you, a...Ch. 16 - A couple has had a child born with...Ch. 16 - You are a genetic counselor, and your patient has...Ch. 16 - Prob. 18QP
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- Huntington’s disease, a neurodegenerative genetic disorder that typically becomes noticeable in middle age, is due to an autosomal dominant allele. Sickle cell anemia, on the other hand, is a genetic blood disorder due to a recessive allele. Jane is a carrier of the allele for sickle cell anemia but has no sign of any neurodegenerative disorder in her family. She married Paul whose father died of Huntington’s disease. His mother, however, is not inflicted with that condition. Neither of his parents exhibit sickle cell anemia. What are the genotypes of Jane and Paul? If they plan to have four children, what is the probability that: all their children will be normal? _________________________________ they will have a son with Huntington’s disease? _________________________ they will have a daughter inflicted with both conditions?________________arrow_forwardHuntington’s disease, a neurodegenerative genetic disorder that typically becomes noticeable in middle age, is due to an autosomal dominant allele. Sickle cell anemia, on the other hand, is a genetic blood disorder due to a recessive allele. Mary is a carrier of the allele for sickle cell anemia but has no sign of any neurodegenerative disorder in her family. She married Paul whose father died of Huntington’s disease. His mother, however, is not inflicted with that condition. Neither of his parents exhibits sickle cell anemia. What are the genotypes of Jane and Paul? If they plan to have four children, what is the probability that: all their children will be normal? _________________________________ they will have a son with Huntington’s disease? _________________________ they will have a daughter inflicted with both conditions?________________arrow_forwardHuntington’s disease, a neurodegenerative genetic disorder that typically becomes noticeable in middle age, is due to an autosomal dominant allele. Sickle cell anemia, on the other hand, is a genetic blood disorder due to a recessive allele. Jane is a carrier of the allele for sickle cell anemia but has no sign of any neurodegenerative disorder in her family. She married Paul whose father died of Huntington’s disease. His mother, however, is not inflicted with that condition. Neither of his parents exhibits sickle cell anemia. What are the genotypes of Jane and Paul?arrow_forward
- A young couple went to see a genetic counselor because each had a sibling affected with cystic fibrosis. (Cystic fibrosis is a recessive disease and neither member of the couple nor any of their four parents is affected). What is the probability that the female of this couple is a carrier and what are the chances that their child will be affected with cystic fibrosis?arrow_forwardHuntington’s disease, a neurodegenerative genetic disorder that typically becomes noticeable in middle age, is due to an autosomal dominant allele. Sickle cell anemia, on the other hand, is a genetic blood disorder due to a recessive allele. Jane is a carrier of the allele for sickle cell anemia but has no sign of any neurodegenerative disorder in her family. She married Paul whose father died of Huntington’s disease. His mother, however, is not inflicted with that condition. Neither of his parents exhibit sickle cell anemia. What are the genotypes of Jane and Paul? Jane:______________________________Paul:_____________________________ If they plan to have four children, what is the probability that: all their children will be normal? _________________________________ they will have a son with Huntington’s disease? _________________________ they will have a daughter inflicted with both conditions?________________arrow_forwardYou met with two parents whose first child has sickle cell anemia. (The parents show no signs of the disease themselves). The mother comes to you in the third month of her second pregnancy, and wants to know if this child will also inherit the disease. As a genetics counselor, you are ready to evaluate this couple’s case by doing the following:1. Determine what the genotype of each parent is. Is this disease autosomal or sex-linked? Dominant or recessive?arrow_forward
- Albinism is an autosomal (not sex-linked) recessive trait. A man and woman are both of normal pigmentation and have one child out of three who is albino (without melanin pigmentation). What are the genotypes of the albino's parents? One parent must be homozygous for the recessive allele; the other parent can be homozygous dominant, homozygous recessive, or heterozygous. Both parents must be homozygous dominant. One parent must be heterozygous; the other parent can be homozygous dominant, homozygous recessive, or heterozygous. Both parents must be heterozygous. One parent must be homozygous dominant; the other parent must be heterozygous. O000arrow_forwardDuchenne muscular dystrophy is sex linked and usually affects only males. Victims of the disease become progressively weaker, starting early in life.a. What is the probability that a woman whose brother has Duchenne’s disease will have an affected child?b. If your mother’s brother (your uncle) had Duchenne’s disease, what is the probability that you have received the allele?c. If your father’s brother had the disease, what is the probability that you have received the allele?arrow_forwardCystic fibrosis in humans is caused by a recessive allele. A man is known to be a carrier of the cystic fibrosis allele. He marries a phenotypically normal woman. In the general population, the incidence of cystic fibrosis at birth is approximately 1 in 1,700. Assume Hardy-Weinberg proportions. What is the probability that the wife is also a carrier? Answer in decimal number only (three decimal places; example: 0.123). What is the probability that their first child will be affected? Answer in decimal number only (three decimal places; example: 0.123).arrow_forward
- Tuberous Sclerosis (TS) is an autosomal dominant genetic disease characterized by seizures, mental retardation, autism, and benign tumors of the brain, heart, skin, and kidneys. The kidney tumors can also be malignant. This disease exhibits a wide range of severity, and only about 1/3 of the cases are inherited. Two different genes have been tightly linked to the disease in families where it is inherited. The remaining 2/3 appear to be due to mutations in one of the 2 genes as well. Overall it appears that 1/2 are caused by mutations in TSC1 and the other half by mutations in TSC2. A rat model for hereditary renal carcinoma (kidney cancer) has been found. Southern and Northern blot analysis of the TSC1 and TSC2 gene revealed no differences between these rats and normal rats. Not all the rats in the strain would get cancer but a significant proportion did and those were selected for and used in experiments. 1. a) What was detected by the Southern blots? (look this up, make your…arrow_forwardA young couple went to see a genetic counselor because each had a sibling with cystic fibrosis. (Cystic fibrosis is a recessive disease, and neither member of the couple nor any of their four parents is affected.) What is the probability that the female of this couple is a carrier? What are the chances that their child will have cystic fibrosis? 3. What is the probability that their child will be a carrier of the cystic fibrosis disease allele?arrow_forwardThe allele for albinism is recessive to the allele for normal skin pigmentation. All individuals who are homozygous for this recessive allele (m) are unable to produce the enzyme needed for melanin production and are referred to as albinos. In the following statements, determine the correct genotypes: An albino male (genotype A) whose parents both have normal skin pigmentation (genotype B) marries a woman who does not have albinism (genotype C). This woman’s father is an albino (genotype D). The married couple has three children, two with normal skin pigmentation (genotype E) and one exhibiting albinism (genotype F)arrow_forward
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