You are given two data sets that provide counts of F1 and F2 offspring with given genders and disease phenotypes.

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You are given two data sets that provide counts of F1 and F2 offspring with given genders and disease phenotypes.

The data are generated from an initial parental cross. One parent displays the disease phenotype and one displays the wild-type (WT) phenotype.The WT parent always has a homozygous genotype.

There are three possible modes of inheritance that underlie the generation of the data. All are monogenic. They are:

(i)   Autosomal Recessive.

(ii)  Homozygous Lethal Dominant.

(iii) Autosomal Dominant.

 

One's phenotype is determined by their genotype at the disease locus and the mode of inheritance, as we have seen with the Punnett Square.

In this file you are provided with the true mode of inheritance.

Your assignment is to perform a chi-square goodness of fit test on each of two F2 data sets, and make a decision, based on your statistical analyses as to which F2 data set provides greater evidence for indicating the correct mode of inheritance.

Evidence is measured in the following ways: the p-value is greater than 0.05, so we do not reject the null hypothesis, and the p-value is closer to 1.

 

A few things of which to be mindful.

  1. In the parental generation, the WT parent always has a homozygous genotype.
  2. For the autosomal dominant moi, the disease is always homozygous for the disease allele.
  3. For the autosomal dominant, homozygous lethal any person with the disease phenotype is heterozygous for their genotype.
  4. The mode of inheritance is the same for both data sets, and so is the parental cross.

 

DATA SET 01

The number of offspring in F1 and F2 generations: 510

The true mode of inheritance is autosomal dominant.

Parental cross: Father with disease phenotype, Mother with wild-type phenotype.

 

F1 COUNTS FOR DATA SET 01

Phenotype

Gender.   Disease     Wild-Type

  Male        237             0

Female       273             0

 

F2 COUNTS FOR DATA SET 01

Phenotype

Gender    Disease     Wild-Type

  Male             185               73

Female           183               69

 

DATA SET 02

The number of offspring in F1 and F2 generations: 899

F1 COUNTS FOR DATA SET 02

Phenotype

Gender   Disease      Wild-Type

  Male          424           0

Female          475         0

 

F2 COUNTS FOR DATA SET 02

Phenotype

Gender      Disease      Wild-Type

  Male             349             112

Female           323             115

can you typed please and this all the information

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