What do you notice is similar about the distribution of the HERC2 variant for blue eyes and the F374 allele for lighter skin pigmentation? Based on what you know about skin color and human variation, what evolutionary circumstances might have caused this distribution of the blue-eye variant?
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What do you notice is similar about the distribution of the HERC2 variant for blue eyes and the F374 allele for lighter skin pigmentation? Based on what you know about skin color and human variation, what evolutionary circumstances might have caused this distribution of the blue-eye variant?
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- The allele of the gene responsible for the lung disorder, cystic fibrosis rose to prominence in Europe in the 1800s. Cystic fibrosis disease results from thick mucus accumulating in the lungs, which occurs in individuals who are homozygous for the CF allele. A pleiotropic effect is that heterozygous individuals are less likely to suffer from diarrhea. During the European cholera epidemics of the 1800s, resistance against diarrhea conferred a survival advantage such that approximately one in every 400 people in some European populations have cystic fibrosis. Fill in the table below with the genotype and allele frequencies for this 1 in 400 occurrence and provide the Hardy-Weinberg principle model you will be using. (Assume that individuals with the cystic fibrosis trait (CF) reproduce normally and that good sanitation means that there is currently no fitness advantage to diarrhea resistance.) phenotype CF DR normal (totals) Genotype cc Cc CC Number of Individuals 1 ______…Sickle cell anemia is caused by a recessive allele at a single gene. As we discussed in class, being a homozygote for the sickle cell allele is almost always lethal, but heterozygotes tend to be resistant against malaria although they have a mild form of anemia. Because of this heterozygote advantage, the allele for sickle cell anemia has a frequency of more than 10% in some human populations. How would present allele frequencies of the sickle cell allele change, if there was no heterozygote advantage or disadvantage (that is, that heterozygotes would be identical to ‘normal’ homozygotes – no malaria resistance, no anemia)? How would the change in sickle cell allele frequencies compare to scenario a (extirpation of malaria)A curious polymorphism in human populations has to do with the ability to curl up the sides of the tongue to make a trough (“tongue rolling”). Some people can do this trick, and others simply cannot. Hence, it is an example of a dimorphism. Its significance is a complete mystery. In one family, a boy was unable to roll his tongue but, to his great chagrin, his sister could. Furthermore, both his parents were rollers, and so were both grandfathers, one paternal uncle, and one paternal aunt. One paternal aunt, one paternal uncle, and one maternal uncle could not roll their tongues.a. Draw the pedigree for this family, defining your symbols clearly, and deduce the genotypes of as many individual members as possible.b. The pedigree that you drew is typical of the inheritance of tongue rolling and led geneticists to come up with the inheritance mechanism that no doubt you came up with. However, in a study of 33 pairs of identical twins, both members of 18 pairs could roll, neither member…
- Certainly, not all Muppets look like the one shown in the picture below, nor do they all look the same. In fact, there’s a great deal of phenotypic variation in Muppets. Two traits that have been particularly well-studied are curly hair presences and skin color. One individual is a male, and he possesses a green skin and no hair, whereas the female individual possess a curly hair and pink skin. Let’s call the gene controlling skin coloration S and that controlling hair H. In this species, both hair and green skin are recessive traits. Both of the individuals shown are homozygous. 1. What is the genotypes of Miss Piggy: 2. Kermit's Genotype: 3. If these two lovebirds (er, love-muppets?) mated, what would their offspring look like? Describe all phenotype combinations possible and the ratios in which they would occur?In humans, the genetic disease cystic fibrosis is caused by a recessive allele (a). The normal (healthy) allele is dominant (A). What is the genotype of someone who has cystic fibrosis? What are the two different genotypes that a healthy person could have? If two people were both heterozygous for the cystic fibrosis gene, what fraction of their children would be likely to have this disease? Hint: Draw a Punnett square to figure it out.In humans, having extra fingers or toes is caused by a dominant allele (E). People with two recessive alleles have 5 fingers and toes on each hand or foot. a. What is the genotype of someone who has 5 fingers and toes on each hand or foot?b. What are the two different genotypes that someone with extra fingers or toes could have?c. If two people both had the normal number of fingers and toes, is there any chance that their children could inherit the allele for extra fingers and toes? Do a Punnett square and show your work.d. If a man who was heterozygous for this gene married someone who was homozygous for the recessive allele, what fraction of their children would you expect to have extra fingers or toes? Do a Punnett square and show your work.
- Suppose that skin color in humans is controlled by 4 gene pairs, and that there are 2 alleles at cach gene pair (a "+" allele and a -"allele). Each "+ allele contributes a unit of pigment above a baseline minimum skin tone, and each "-" allele contributes no additional pigment. Which of the following genotypes would produce the same phenotype as A A BB CC D'D? Assume that exposure to sunlight and/or tanning beds are equal for all individuals. OA'A*B* B* CC D'D OA*A BBc c*D'DSince we are all so closely related, it is amazing that we see such tremendous diversity in the human population. List three reasons why phenotypic traits such as skin color, eye color or collagen production can vary so widely. For each reason you state, you must fully describe how that particular genetic phenomenon works.Using the HardyWeinberg Law in Human Genetics Suppose you are monitoring the allelic and genotypic frequencies of the MN blood group locus (see Question 2 for a description of the MN blood group) in a small human population. You find that for 1-year-old children, the genotypic frequencies are MM = 0.25, MN = 0.5, and NN = 0.25, whereas the genotypic frequencies for adults are MM = 0.3, MN = 0.4, and NN = 0.3. a. Compute the M and N allele frequencies for 1-year-olds and adults. b. Are the allele frequencies in equilibrium in this population? c. Are the genotypic frequencies in equilibrium?
- You are studying the genetics of a newly discovered small animal. You note that most of the population is black in colour but about 1/4 of them are white. You have determined that there is a gene (B) that produces an enzyme that converts a pigment molecule to produce the Black colour. There are 2 alleles of this gene - the dominant B and the recessive b. DNA analysis shows that black individuals have either a BB or Bb genotype and that white individuals have a bb phenotype. However, after extensive DNA analysis, you have discovered that a small percentage of White individuals have either a BB or Bb genotype. Describe two reasons (at a molecular level) that could explain this apparent anomaly. There wasn't a mistake in analysis! These individuals did have a BB or Bb genotype but a white phenotype.As discussed in the text, almost 5% of Caucasians carry a recessive gene for cystic fibrosis. Until recently, most people with cystic fibrosis died in childhood or early adulthood. Why is cystic fibrosis so frequent in spite of the fact that until recently it was usually lethal?With regard to the ABO blood types in humans, determine the genotypes of the individuals below: John: John is blood type A and his mom was type B Genotype = Jane: Jane is blood type B and her dad was type O Genotype John and Jane have kids. What are the possible blood types of their offspring, including the expected ratio of each? O John is A1", Jane is l'i, the blood type ratios of their children would be: 1 AB: 1A : 1B John is IA, Jane is l1", the blood type ratios of their children would be: 1 AB: 1 B John is 1Ai. Janc is iP1P, the blood typc ratios of their children would be: 1 AB: 1 A: 1B John is Jane is IPi, the blood type ratios of their children would be 1 AB : 1A 1B:10