Topic: Pharmaceutical chemistry. Biosynthesis of secondary metabolites. 1. Circle the biosynthetic units of crosanthin O and name them. .COOH HO Figure. Structure of Crosanthin O (from Gardenia jasminoides fruits)
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- These are option to choose and fill. 1.a.very acidicb.neutralc.very basic 2.a.asparagine and glutamineb.arginine and lysinec.phenylalanine and tyrosine 3.a.neutralb.negatively chargedc.aromaticd.positively charged 4.a.negatively charged phosphatesb.positively charged phosphatesc.aromatic nucleotidesd.neutral phosphoric acid groups 5.a.lose their aromatic side chainsb.lose their positive chargec.lose their negative charged.increase their positive chargee.increase their negative charge 6.a.more attraction to the phosphatesb.no attraction to the phosphatesc.no attraction to the aromatic groups 7.a.not as unfavorable becauseb.even less favorable becausec.comparatively favorable even though 8.a.carry negative chargesb.carry positive chargesc.are neutralENZYMES. Match the name of the enzyme with the biochemical reaction. Enzymes may be used more than once a. amylase 1. casein hydrolysis b. cysteine desulfurase 2.gelatin liquefaction c. lipase 3. hydrogen sulfide production d. protease 4. indole e. tryptophanase 5.starch hydrolysis f.urease 6.triglyceride hydrolysis urea hydrolysisShort examination of Advanced Medicinal Chemistry course 1. What is the Reverse transcriptase (RT) inhibitors? Explain with an example and describe its structure. 2. What is the oral absorption of a drug? Describe completely. 3. What is the following structure about? Describe with details. PEPTIDE(1) PEPTIDE(1) NH NH NH HN CO---- ---HN 0 SERINE PROTEASE 0= YX MIX HN Co,H O CO₂H PENICILLINS CO₂H ---HN SERINE PROTEASE 4. Mention to the five Protease inhibitors containing sulfonamide functional moiety. 5. Explian the H2 Receptor Antagonists. 6. Write the synthesis pathway for the Zantac. NHMe none NO₂ ranitidine (Zantac) 7. Explain the cyclin-dependent kinases, completely. 8. Describe DNA ALKYLATING AGENTS. R
- I. Predict the outcome of the following reactions. If positive write what will you observe (color, name of the product). If negative, explain the reason why. NH Orcinol но NH2 A 1.) ÓH H. Но NH 2.) ОН ОН HO-P-O-P-0-P- OH (NH4)ẠM0O4 ÓH OH ÓH Conc. HNO3 3.) Он H Conc. HNO3 HN -NH N. КОН 4.) H3C NH HO Brz in H20 Ba(OH)2 HO- 5.) ÓH%3D NHA H. Download Image... One of the products released by the action of phospholipase Aj on the lipid is O A. Palmitic acid O B. Stearic acid OC Oleic acid O D. Linoleic acid A Moving to another question will save this response.PRODUCTS. Match the name of the product with the biochemical reaction. Products may be used more than once. Tests may require more than one answer. a. 2,3-butanediol b. ammonia c. fatty acids d. indole e. molecular oxygen f. phenylpyruvic acid catalase phenylalanine deamination triglyceride hydrolysis tryptophan degradation urea hydrolysis Voges-Proskauer test
- topic: ISOLATION AND CHARACTERIZATION OF CARBOHYDRATES 1. Erythrose is an aldoterose. Describe the result when it is subjected to each of the following tests:a. Molisch’s Testb. Barfoed’s Testc. Benedict’s Testd. Seliwanoff’s Test2. Illustrate the reaction and identify the principle involved in the Nelson test.topic: ISOLATION AND CHARACTERIZATION OF CARBOHYDRATES 1. Describe the reaction that takes place when starch is hydrolyzed by an enzyme. What is the product of starch hydrolysis? 2. What enzyme is present in the saliva? What conclusion can be made regarding the action of this enzyme on starch?I. Predict the outcome of the following reactions. If positive write what will you observe (color, name of the product). If negative, explain the reason why. NH Orcinol но- NH2 A 1.) OH 'NH но NH A 2.) ОН ОН HO-P-O-P-O он (NH4)4MOO4 OH OH OH Conc. HNO; 3.) OH
- me (1).docx BIU A A- are they different? 3. What are three ways that 2-deoxystreptamine (2-DOS) aminoglycosides can inhibit protein synthesis? 4. Chloramphenicol: a. Where does this drug bind? b. How does it inhibit protein synthesis?5. Matching Type Match Column A with Column B. Write your answer on the space provided. CAPITAL letters only. Column A Column B 1.. Citrate → Isocitrate 2. Fumarate → Malate 3. Fructose-1,6-bisphosphate → G3P and DHAP 4. PEP → Pyruvate 5. a-Ketoglutarate → Succinyl-CoA 6. Substrate-level phosphorylation 7. Oxidative decarboxylation 8. Reduction 9. Isomerization 10. Condensation 11. Fumarate → Malate 12. Citrate → Isocitrate 13. Succinate → Fumarate 14. Succinyl-CoA → Succinate 15. Malate → Oxaloacetate 16. Pyruvate → Acetaldehyde 17. Pyruvate → Acetyl-CoA 18. PEP → Pyruvate 19. 2-Phospoglycerate → PEP 20. Glucose Glucose-6-phosphate A. Succinate dehydogenase B. Succinyl-CoA synthetase C. Malate dehydrogenase D. Fumarase E. Citrate synthase E. Isocitrate → a-Ketoglutarate F. 3-Phosphoglycerate → 2-Phosphoglycerate F. Aconitase G. Acetyl-CoA + Oxaloacetate → Citrate G. Glycolysis H. Pyruvate → Lactate I. Glucose-6-phosphate → Fructose-6-Phosphate K. Kreb's cycle U. Enolase V. Hexokinase…Long explanations are not needed. Direct answers would suffice. a. Which of the following is not a complex conjugated carbohydrate? I. lipopolysaccharide II. proteoglycan III. glycoprotein IV. peptidoglycan V. oligosaccharide b. Gluconic acid is derived from _______ while glucuronic acid is derived from ______. I. glucose: gulose II. galactose: glucose III. gulose: glucose IV. glucose: glucose V. glucose: galactose