The results of QTL mapping studies for human diseases tend to show that disease-causing alleles are either rare or have very small effects on risk. Knowing that this is true, discuss the evolutionary forces that are most likely to be responsible for this state of affairs. Does this observation suggest something about the evolutionary forces that maintain disease risk in human populations?
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The results of QTL mapping studies for human diseases tend to show that disease-causing alleles are either rare or have very small effects on risk. Knowing that this is true, discuss the evolutionary forces that are most likely to be responsible for this state of affairs. Does this observation suggest something about the evolutionary forces that maintain disease risk in human populations?
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- The prevalence (frequency) of sickle-cell disease in Canada is quite low, affecting 1/3800 individuals. However, in some African populations 1/25 individuals are affected by sickle-cell disease. The difference in frequency of this allele within the differing populations has to do with the adaptation pressures that exist in the different environments. Individuals with the heterozygous genotype have a survival advantage in environments where the disease malaria is prevalent as the presence of this mutant allele leads to resistance to malaria. Therefore, the sickle-cell disease tends to be more frequent in environments where the malaria parasite is most common. Question: Explain why the sickle-cell disease remains frequent in some populations while it exists in very low frequency in other populations.Apply the VIDA table to the evolution of sickle cell disease to justify whether it is an instance of evolution by natural selection. Answer the following questions. Is there variation in this trait in the population? How exactly does it vary? Is the trait at least partly inherited? Is there selection for this trait in a particular environment? (What is the selective pressure? And how does a trait give an advantage or disadvantage in that environment?) What is the evidence that this trait makes organisms better adapted to their environment?Human immunodeficiency virus entered human populations after evolving from a simian immunodeficiency virus. Nikolaas Tinbergen (1963)1 proposed explaining shifts in traits from two perspectives: dynamic versus static, and proximate versus ultimate. This framework can be used to understand the evolution of a trait in four ways: (i) causation (proximate/static): the mechanism of the trait as it works in the present; (ii) survival value (ultimate/static): how function of the trait enhances survival or reproduction; (iii) ontogeny (proximate/dynamic): the development of the trait in an individual; and (iv) evolution (ultimate/dynamic): the phylogenetic history of the trait. Use these categories to discuss the causes for the virus shifting to humans from other primates.
- Microbiologists have discovered that alleles associated with antibiotic resistance are present in bacteria that live in soil, even in environments that are comparatively free of antibiotic pollution from human activities. Why are such alleles present (albeit at low levels) in bacterial populations? Conversely, if resistance alleles are beneficial, why are they rare in natural populations of bacteria?Steven Frank and Laurence Hurst argued that a cytoplasmically inherited mutation in humans that has severe effects in males but no effect in females will not be eliminated from a population by natural selection because only females pass on mtDNA (S. A. Frank and L. D. Hurst. 1996. Nature 383:224). Using this argument, explain why males with Leber hereditary optic neuropathy are more severely affected than females.PINE TREE NEEDLES Variation among members of a population can lead to natural selection, but only if two conditions are met: First, the trait must be relevant to an individual's survival and/or reproductive rate. Second, variation in this trait must be heritable, that is, at least partly controlled by genes. a. How might you design an experiment to determine the importance of needle length in determining survival and reproduction? b. How might you test the extent to which needle length is heritable?
- Evolution determines the change in inherited traits over time to ensure survival. There are three variants identified as Variant 1 with high reproductive rate, eats fruits and seeds; Variant 2, thick fur, produces toxins; and Variant 3 with thick fur, fast and resistant to disease. These variants are found in a cool, wet, and soil environment. In time 0 years with cool and wet environment, the population is 50,000 with 10,000 Variant 1, 15,000 Variant 2, and 25,000 of Variant 3. Two thousand years past, the environment remained the same with constant average temperature and rainfall. Variant 1 with a population of 26,000, Variant 2, 35,000, and Variant 3, 62,000. A disease spread throughout the population. However the population increased to 72,000. Determine the percentage increase in the population of the variants.Assume that 10% of the members of a population will get a particular disease over the course of their lifetime. Genomic studies reveal that 5% of the population have sequences in their genomes such that their probability of getting the disease over the course of their lifetimes is 50%. What is the average lifetime risk of this disease for the remaining 95% of the population without these sequences?In parts of equatorial Africa, where the malaria parasite is most common, the sickle-cell allele constitutes 20% of the ß-hemoglobin alleles in the human gene pool. The sickle cell trait provides an advantage against malaria compared to people with normal hemoglobin. In the United States, the parasite that causes malaria is not present, but African Americans whose ancestors were from equatorial Africa have the sickle-cell B- hemoglobin allele. These differences in traits illustrate O inclusive fitness because people have evolved molecular differences to adapt to environmental stimuli O inclusive fitness because ß-hemoglobin increases the proliferation of beneficial traits in the population O relative fitness because people have evolved molecular differences to an environmental pathogen O relative fitness because the molecular differences in ß-hemoglobin are passed to the next generation
- Cerebellar abiotrophy (CA) is a recessive, genetic neurological disease found in the Arabian horse breed. If the incidence of this disease is about 1 in 400 Arabian horses, estimate the frequency of carriers in a population in Hardy-Weinberg equilibrium. Value of q²: 0.0025 Value of q: 0.05 Value of p: 0.95 Carrier Frequency: 0.095 How many horses would you expect to be carriers for cerebellar abiotrophy if the population consists of 582 Arabian horses? (Round to the nearest whole number and enter 2 digits.)How does the aminoacyl trna synthetases recognize which trna gets its amino acid? Define compare and contrast and give examples of natural selection and the impact on allele frequencies through mechanisms such as stabilizing selection directional selection and disruptive selection?In the human brain a great deal of synaptic pruning occurs in early childhood?n class we investigated the reason cystic fibrosis is maintained in the human population in higher frequency than we expected given the deleterious effects of being homozygous at the CFTR gene. We calculated the actual mutation rate of the CFTR gene to be 6.7 x 10-7. The mutation rate expected under mutation-selection balance was 4 x 10-4. What is the most plausible explanation as to why cystic fibrosis is maintained in the human population at a higher frequency than we expect? a. Negative selection against the CFTR deleterious alleles is too weak to eliminate the alleles from the human population. b. Positive selection for the CFTR deleterious alleles is likely occurring in response to some other selective pressure in the human population, possibly resistance to typhoid fever. c. The CFTR gene has an exceedingly low mutation rate causing humans to have no genetic variation at that gene. d. The CFTR gene has an exceedingly high mutation rate and that is…