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Curren'S Math For Meds: Dosages & Sol

Curren'S Math For Meds: Dosages & Sol

11th Edition

ISBN:9781305143531

Author:CURREN

Publisher:CURREN

Chapter21: Heparin Infusion Calculations

Section: Chapter Questions

Problem 1.3P

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7. A 22-year-old patient suffering argininosuccinic aciduria from little was
prescribed the treatment by administration of keto-analogs of valine, leucine,
isoleucine and phenylalanine against the background of reduced protein in the
diet during two weeks. The doctor noted the decreasc of ammonia concentration
in plasma from 0.09 mg/dL to 0.04 mg/dL as a result, and arginine succinate
excretion was reduced from 2 to 0.8 g/24h. What is the molecular mechanism of
the curative effeet of amino acids keto-analogs? For the answer:
a) write down the scheme of ammonia detoxification in the liver;
b) explain the cause of argininosuccinic aciduria;
c) make up the scheme of present amino acid keto-analogs usage for the
reduction of hyperammoniemia.

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