R :X 2 X R A. Inspect the figure. Draw a reaction coordinate diagram (energy vs reaction progress) that shows the enzyme- catalyzed reaction (as shown above) and uncatalyzed reaction. Make sure your sketch accurately reflects relative free energies of various species. B. What are the chemical roles of 1 and 2 in the enzyme-catalyzed reaction shown in Model 3? C. Propose specific amino acid side chains that could best serve the functions of 1 and 2 in the enzyme depicted in Model 3. Justify your choices.

R :X 2 X R A. Inspect the figure. Draw a reaction coordinate diagram (energy vs reaction progress) that shows the enzyme- catalyzed reaction (as shown above) and uncatalyzed reaction. Make sure your sketch accurately reflects relative free energies of various species. B. What are the chemical roles of 1 and 2 in the enzyme-catalyzed reaction shown in Model 3? C. Propose specific amino acid side chains that could best serve the functions of 1 and 2 in the enzyme depicted in Model 3. Justify your choices.

Chemistry & Chemical Reactivity

10th Edition

ISBN:9781337399074

Author:John C. Kotz, Paul M. Treichel, John Townsend, David Treichel

Publisher:John C. Kotz, Paul M. Treichel, John Townsend, David Treichel

Chapter14: Chemical Kinetics: The Rates Of Chemical Reactions

Section14.7: Reaction Mechanisms

Problem 1.2ACP

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