Question 18) Very early onset PSEN2 mutations have a more severe impact on the Aß 42/40 ratios than mutations that cause onset at a later age? Select one: O True O False

Curren'S Math For Meds: Dosages & Sol
11th Edition
ISBN:9781305143531
Author:CURREN
Publisher:CURREN
Chapter5: Unit, Percentage, Milliequivalent, Ratio, And Household Measures
Section: Chapter Questions
Problem 2.4P
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To further understand PSEN2 mutations the age of onset of
Alzheimer's Disease and AB 42/40 ration is investigated for different
mutations in PSEN2.
Table 3 - Age at onset of FAD and
measured Aß 42/40 ratios for each
patient.
PSEN2
Mutation
Age at
onset
(Years)
AB 42/40
ratio
PSEN2
WT
Select one:
True
False
N/A
1
1229F M223L F237P M233V F237L N410Y
33
7.3+
0.7
46 35
3.81
32
4.5
0.2 0.4
14.7
52 31
2.2 ±
1.2 1.8
20.76 +
Question 18) Very early onset PSEN2 mutations have a more severe
impact on the AB 42/40 ratios than mutations that cause onset at a
later age?
Transcribed Image Text:To further understand PSEN2 mutations the age of onset of Alzheimer's Disease and AB 42/40 ration is investigated for different mutations in PSEN2. Table 3 - Age at onset of FAD and measured Aß 42/40 ratios for each patient. PSEN2 Mutation Age at onset (Years) AB 42/40 ratio PSEN2 WT Select one: True False N/A 1 1229F M223L F237P M233V F237L N410Y 33 7.3+ 0.7 46 35 3.81 32 4.5 0.2 0.4 14.7 52 31 2.2 ± 1.2 1.8 20.76 + Question 18) Very early onset PSEN2 mutations have a more severe impact on the AB 42/40 ratios than mutations that cause onset at a later age?
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