Below is a pedigree showing transmission of a disease; affected individuals areindicated by solid circles or boxes. Represented below the pedigree are two nylon membranes; DNAsamples from each individual in the pedigree were spotted in identical fashion on each membrane. Eachindividual's DNA appears directly below his or her position in the pedigree. Each membrane washybridized with allele specific oligonucleotides that detect the two alternative alleles of a single SNP locus(ASO 1 and ASO 2). Positive hybridization is represented as a filled circle and lack of hybridization isrepresented as an open circle.I11IIIIVVASO 1ASO 2To1 2 3 4 5 6a. What is the mode of transmission of this disease?12b. Which SNP allele (ASO1 or ASO2) is originally linked to the disease gene?c. Draw a diagram of the event that gave rise to the genotype of individual IV-5.d. Individual V-1 is an unborn fetus. If the SNP locus is 10 CM from the disease locus, what is thelikelihood that he will express the disease phenotype? Show your work.

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Description: Below is a pedigree showing transmission of a disease; affected individuals areindicated by solid circles or boxes. Represented below the pedigree are two nylon membranes; DNAsamples from each individual in the pedigree were spotted in identical fas

a ) the mode of transmission is autosomal dominant. b) ASO1 is linked for disease transmission.

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a. What is the mode of transmission of this disease? b. Which SNP allele (ASO1 or ASO2) is originally linked to the disease gene? c. Draw a diagram of the event that gave rise to the genotype of individual IV-5.

a. What is the mode of transmission of this disease? b. Which SNP allele (ASO1 or ASO2) is originally linked to the disease gene? c. Draw a diagram of the event that gave rise to the genotype of individual IV-5.

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter4: Pedigree Analysis In Human Genetics

Section: Chapter Questions

Problem 10QP: A proband female with an unidentified disease seeks the advice of a genetic counselor before...

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