In the image below, six diploid individuals are analyzed with regard to three different alleles (A, B, & C) of the same SSR. What are the genotypes of individuals 1, 3, and 6 (highlighted below)? 4 5 6 Allele A B C 1 2 3 O 1: CC; 3: AA; 6: AB O1: ABC; 3: ABC; and 6: ABC 1: C; 3: A; 6: B O1: AB; 3: BC; 6: CC Direction of electrophoresis
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- 1. The figure below shows a pedigree examining the presence of a genetic disorder across multiple generations of a family. Based off this figure, answer the following questions prompted: || IV 3 9 10 5 2 C 6 11 T 7 12 8 15 13 16 14 17 d) What is the genotype for individual #4 in this family pedigree? ||| c) Why are no family members identified as a carrier of this genetic disorder? Figure Key a) Using the figure key provided, identify which members of this family are affected by this genetic disorder in each generation. (Be sure to include sex and generation number for each individual identified). b) Is this an autosomal recessive, autosomal dominant, or sex-linked genetic disorder? Explain. Unaffected Female Unaffected Male Affected Female ||| Affected Male Female Carrier Male CarrierEnsure answers are clearly labelled a) & b). a) Consider the following pedigree. The solid symbols represent affected individuals. Which of the following is / are possible genotypes for II-2 with respect to this disease? Please type 1 - 4, and indicate yes or no only for each. II III 1. xAxa 2. xaxa 3. Aa 4. AA2 b) Genes A, B and C are on the same chromosome linked in cis (coupling) conformation. A'is 16 cM from B, and B is 22 cM from C. The distance between A and C is 38 cM. The coefficient of coincidence is 0.55 for a trihybrid test cross. How many individuals with the genotype AabbCc do you expect to see among the offspring of the cross if 1000 offspring are obtained? Please show your calculations and round your answer off to the nearest whole number.If a Mother's genotype is IAi and her Daughter's genotype is ii and the mother claims a man who is type B as the father... a) Is that possible? Explain. b) The accused man can prove that both of his parents are type AB. Is it possible for him to be type B? If so, what is his genotype? Explain. d) Does the answer in part c change the answer in part b? Explain.
- Given these parents-note, they are NOT quite the same as each other!: mom = Aa Bb Cc Dd dad = Aa Bb cc Dd NOTE that the A gene acts incompletely dominantly. a) What chance does their baby having the "strongest phenotype" in A, being recessive in b, recessive in c, and dominant in D? Give one fraction. Show work. b) phenotype? Now assume mom was CC instead of Cc. Now what is the chance of having that sameBelow is a pedigree of a human blinding disease. Use this pedigree to answer the following questions. 95 ㅇㅇ If this is disease has an autosomal recessive inheritance pattern, how many of the individuals in this pedigree have genotypes that are known for certain? a) 13 b) 9 c) 10 d) 12 e) 11Consider the first category of test-cross offspring shown in figure 8.2 (+b, LS). Consider also that the parents of the heterozygous female flies in the test cross had the following genotypes: bb, SS, and +, LL. A. What would be the physical phenotype of these flies? B. If PC was conducted with the DNA of one of these flies using the primers for the molecular marker, what would be the appearance of the bands on an electrophoresis gel with the PC products? C. If the gene for black body and the locus for the molecular marker (L long or S short) were unlinked, what proportion of the test-cross progeny would be black flies that are heterozygous for the molecular marker? What proportion would be flies with normal body color, which are homozygous for one form of the molecular marker? D. If the gene for black body and the locus for the molecular marker were linked, how would the proportion of flies be different?
- Below is a pedigree of a human blinding disease. Use this pedigree to answer the following questions. If this is disease has an autosomal recessive inheritance pattern, what is the probability that if individuals IV-5 and III-5 had and offspring it would exhibit the disease? a) 25% b) 33% c) 11% d) 17% e) 6%A female is homozygous for a dominant mutation of ACE2 which prevents binding of the spike protein from Covid-19. This woman marries a man that does not contain any mutation for ACE2. Considering the bar body, what would this mean for chances of their daughters being more protected from Covid-19 in the future. What about the sons? Select one: a. Each daughter would have a 50% chance of being essentially immune to Covid 19 due to mosaicism and inactivation of one X. If the X with the wild-type allele for ACE2 is suppressed as the bar body, the women would be more resistant to COVID-19, if the X with the mutant form is suppressed, the daughter have the normal reaction to COVID-19. Each son will be immune. b. Since the ACE2 receptor has nothing to do with the sex chromosomes, then each daughter will be heterozygous for the mutation and both the sons and daughters will be immune to COVID-19. c. Since females have two X's, each daughter will be twice as affected by COVID-19.The human MN blood group is determined by alleles (M and N) of a single gene that code for twO specific markers found on the surface of red blood cells. These alleles show a codominant pattern of expression. Blood typing of one family shows that the offspring all have the genotype MN. What are the most probable genotypes of the parents in this family? A)MM and NN B)ONN and MN C)MN and MN D)MM and MN
- Consider the first category of test-cross offspring shown in figure 8.2 (+b, LS). Consider also that the parents of the heterozygous female flies in the test cross had the following genotypes: bb, SS, and +, LL. A. What would be the physical phenotype of these flies? B. If PCR was conducted with the DNA of one of these flies using the primers for the molecular marker, what would be the appearance of the bands on an electrophoresis gel with the PCR products? C. If the gene for black body and the locus for the molecular marker (L long or S short) were unlinked, what proportion of the test-cross progeny would be black flies that are heterozygous for the molecular marker? What proportion would be flies with normal body color, which are homozygous for one form of the molecular marker? D. If the gene for black body and the locus for the molecular marker were linked, how would the proportion of flies be different?For the following question, please explain in as much detail as possible. Below is a human pedigree and corresponding RFLP data. Explain the type of transmission for the type of albinism depicted in this family. What does the pedigree tell you about the individual labeled Y's genotype? There are two genes known to cause this type of albinism found in this family: OCA1 and OCA2. If we know 1 (albino great grandmother) had mutation in OCA1 which gene would you hypothesize is mutated in individual Y's genome? Explain your reasoning. generations Key: D ở abino Ped. III2 II13 IV1 IV 2 IV3 IV4 IV5 IV6 III13 III14 IV 15 IV16 IV17 ID (P) (Q) (X) (Y) Band size 20kb 15kb X 12kb 10kb X X 8kb X X X 5kb X X X X X X X X 3kb 2kbA man of blood group B is being sued by a woman of blood group A for paternity. The womans child is blood group O.a) If this man is actually the father of this child, specify the genotypes of both parents?b) If it was impossible for this group B man to be the father of a type O child, specify his genotype?c) If a man was blood group AB, could he be the father of group O child?