Homework Help is Here – Start Your Trial Now!
Science
Biology
FIGURE 20.2 The Holliday model for homologous recombination. The Holliday model is adapted from R. Holliday (1964), A mechanism for gene conversion in fungi. Genet Res 5, 282–304. (b): From: H. Potter and D. Dressler, "DNA Recombination: In Vivo and In Vitro Studies," Sister chromatids ONLINE ANIMATION Homologous chromatids Cold Spring Harb Symp Quant Biol 1979. 43: 969-985, ©Cold Spring Harbor Laboratory Press. Image provided by Huntington Potter, Ph.D. a b CONCEPT CHECK: Explain why a heteroduplex region may be produced after branch migration occurs. 3' Both chromatids are nicked at 'identical locations. Nicks The DNA strands to the left of the nicks invade the homologous chromatids and covalently link to the strands to the right of the nicks. -Holliday junction The Holliday junction migrates from left to right. This is called branch migration. It creates 2 heteroduplex regions. (b) Micrograph of a Holliday junction Two heteroduplex regions that have a few base mismatches In this next step, the figure is simply redrawn by bending | the ends labeled A and B upward, and bending the ends labeled a and b downward. This makes it look more like a true Holliday junction. The Holliday junction is viewed in two different planes. End result A B в в The strands are Short connected to create nonrecombinant The strands that were originally nicked are broken. chromosomes with a short heteroduplex region. heteroduplex region a b Nonrecombinant chromosomes with a heteroduplex region Viewed in a different plane |(when rotated 180°) AB в, The strands that were not originally nicked are broken. в, The strands are connected Short heteroduplex region to create recombinant chromosomes with a short heteroduplex region. аь Recombinant chromosomes with a heteroduplex region (a) The Holliday model for homologous recombination

FIGURE 20.2 The Holliday model for homologous recombination. The Holliday model is adapted from R. Holliday (1964), A mechanism for gene conversion in fungi. Genet Res 5, 282–304. (b): From: H. Potter and D. Dressler, "DNA Recombination: In Vivo and In Vitro Studies," Sister chromatids ONLINE ANIMATION Homologous chromatids Cold Spring Harb Symp Quant Biol 1979. 43: 969-985, ©Cold Spring Harbor Laboratory Press. Image provided by Huntington Potter, Ph.D. a b CONCEPT CHECK: Explain why a heteroduplex region may be produced after branch migration occurs. 3' Both chromatids are nicked at 'identical locations. Nicks The DNA strands to the left of the nicks invade the homologous chromatids and covalently link to the strands to the right of the nicks. -Holliday junction The Holliday junction migrates from left to right. This is called branch migration. It creates 2 heteroduplex regions. (b) Micrograph of a Holliday junction Two heteroduplex regions that have a few base mismatches In this next step, the figure is simply redrawn by bending | the ends labeled A and B upward, and bending the ends labeled a and b downward. This makes it look more like a true Holliday junction. The Holliday junction is viewed in two different planes. End result A B в в The strands are Short connected to create nonrecombinant The strands that were originally nicked are broken. chromosomes with a short heteroduplex region. heteroduplex region a b Nonrecombinant chromosomes with a heteroduplex region Viewed in a different plane |(when rotated 180°) AB в, The strands that were not originally nicked are broken. в, The strands are connected Short heteroduplex region to create recombinant chromosomes with a short heteroduplex region. аь Recombinant chromosomes with a heteroduplex region (a) The Holliday model for homologous recombination

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
See similar textbooks
icon
Related questions
icon
Concept explainers
Question

In the Holliday model for homologous recombination shown,                       the resolution steps can produce recombinant or nonrecombinant
chromosomes. Explain how this can occur.

FIGURE 20.2 The Holliday model for homologous recombination. The Holliday model is adapted from R. Holliday (1964), A mechanism for gene conversion in fungi. Genet Res 5, 282–304. (b): From: H. Potter and D. Dressler, "DNA Recombination: In Vivo and In Vitro Studies," Sister chromatids ONLINE ANIMATION Homologous chromatids Cold Spring Harb Symp Quant Biol 1979. 43: 969-985, ©Cold Spring Harbor Laboratory Press. Image provided by Huntington Potter, Ph.D. a b CONCEPT CHECK: Explain why a heteroduplex region may be produced after branch migration occurs. 3' Both chromatids are nicked at 'identical locations. Nicks The DNA strands to the left of the nicks invade the homologous chromatids and covalently link to the strands to the right of the nicks. -Holliday junction The Holliday junction migrates from left to right. This is called branch migration. It creates 2 heteroduplex regions. (b) Micrograph of a Holliday junction
Transcribed Image Text:FIGURE 20.2 The Holliday model for homologous recombination. The Holliday model is adapted from R. Holliday (1964), A mechanism for gene conversion in fungi. Genet Res 5, 282–304. (b): From: H. Potter and D. Dressler, "DNA Recombination: In Vivo and In Vitro Studies," Sister chromatids ONLINE ANIMATION Homologous chromatids Cold Spring Harb Symp Quant Biol 1979. 43: 969-985, ©Cold Spring Harbor Laboratory Press. Image provided by Huntington Potter, Ph.D. a b CONCEPT CHECK: Explain why a heteroduplex region may be produced after branch migration occurs. 3' Both chromatids are nicked at 'identical locations. Nicks The DNA strands to the left of the nicks invade the homologous chromatids and covalently link to the strands to the right of the nicks. -Holliday junction The Holliday junction migrates from left to right. This is called branch migration. It creates 2 heteroduplex regions. (b) Micrograph of a Holliday junction
Two heteroduplex regions that have a few base mismatches In this next step, the figure is simply redrawn by bending | the ends labeled A and B upward, and bending the ends labeled a and b downward. This makes it look more like a true Holliday junction. The Holliday junction is viewed in two different planes. End result A B в в The strands are Short connected to create nonrecombinant The strands that were originally nicked are broken. chromosomes with a short heteroduplex region. heteroduplex region a b Nonrecombinant chromosomes with a heteroduplex region Viewed in a different plane |(when rotated 180°) AB в, The strands that were not originally nicked are broken. в, The strands are connected Short heteroduplex region to create recombinant chromosomes with a short heteroduplex region. аь Recombinant chromosomes with a heteroduplex region (a) The Holliday model for homologous recombination
Transcribed Image Text:Two heteroduplex regions that have a few base mismatches In this next step, the figure is simply redrawn by bending | the ends labeled A and B upward, and bending the ends labeled a and b downward. This makes it look more like a true Holliday junction. The Holliday junction is viewed in two different planes. End result A B в в The strands are Short connected to create nonrecombinant The strands that were originally nicked are broken. chromosomes with a short heteroduplex region. heteroduplex region a b Nonrecombinant chromosomes with a heteroduplex region Viewed in a different plane |(when rotated 180°) AB в, The strands that were not originally nicked are broken. в, The strands are connected Short heteroduplex region to create recombinant chromosomes with a short heteroduplex region. аь Recombinant chromosomes with a heteroduplex region (a) The Holliday model for homologous recombination
Expert Solution
trending now

Trending now

This is a popular solution!

steps

Step by step

Solved in 2 steps

SEE SOLUTIONCheck out a sample Q&A here
Blurred answer
Knowledge Booster
Genetic recombination
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:
9780815344322
Author:
Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:
W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:
9781260159363
Author:
Martin, Terry R., Prentice-craver, Cynthia
Publisher:
McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Inquiry Into Life (16th Edition)
Biology
ISBN:
9781260231700
Author:
Sylvia S. Mader, Michael Windelspecht
Publisher:
McGraw Hill Education
SEE MORE TEXTBOOKS