Explain the processes of upregulation and downregulation and how these processes lead to tolerance and withdrawal, using opioids as an example. Because of repeated administration of opioids, what changes happen in the nervous system, and what are BOTH the acute effects of opioid use and withdrawal symptoms from opioids.

Essentials of Pharmacology for Health Professions
7th Edition
ISBN:9781305441620
Author:WOODROW
Publisher:WOODROW
ChapterCRE2: Comprehensive Review Exam For Part 2
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Problem 29CEP2
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Explain the processes of upregulation and downregulation and how these processes lead to tolerance and withdrawal, using opioids as an example. Because of repeated administration of opioids, what changes happen in the nervous system, and what are BOTH the acute effects of opioid use and withdrawal symptoms from opioids.

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