Critically discuss the split nature of tumour infiltrating lymphocytes (TILs) in the tumour microenvironment and how this has led to the development of specific immunotherapies
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Critically discuss the split nature of tumour infiltrating lymphocytes (TILs) in the tumour microenvironment and how this has led to the development of specific immunotherapies
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- Discuss the involvement of T cells in organ transplantation and thedifferent ways that grafted tissues may be rejected.reveiw the evidence for and againt the importance of inflammatory response genes of the CIN, MSI, CIMP pathways that are involved in regards to adenocarcinoma tumours colorectal cancer (colon) Provide detailed analysis with examples.Describe the cancer immunotherapy that won the Nobel Prize in 2018. Please include: how they discovered the mechanism of action describe the mechanism of action what drug did they developed
- Illustrate the development of T-cells and B-cells comparing the stages and steps in these two processes. Draw the two schematics side by side to align the comparative stages (progenitors to mature cells) and steps and point out the key common mechanisms and differences if any. This needs to be a labeled drawing please.Topic: A patient was diagnosed with lymphoma in 2019. The tumor metastasized to multiple sites of the body. In 2020, the same patient was infected with COVID-19. Upon recovery from the infection, the physician performed a CT scan and noticed tumor complete remission. Using your knowledge in immunology, can you described what may have accounted for the complete remission?Neoplastic cells typically evade immunosurveillance. Explain how this occurs and describe how targeting tumour-mediated immune suppression has led to novel cancer immunotherapeutics
- Discuss the role of immunosuppressive therapy in organ transplantation and in the treatment of autoimmune diseases.Describe the significance and need for receptor editing as a part of elimination of self-reactive B lymphocytes.Tumour associated macrophages (TAMS) represent up to 50% of cells in solid tumours. Explain how these cells contribute to immunosuppression in the tumour microenvironment and how they help tumour cells to evade anti-tumour immune responses
- Discuss how our knowledge of cytotoxic T- cell function and regulation has been exploited for the development of cancer immunotherapies.The adaptive response is a robust and critical component of the immune systemis able to combat specific microbial pathogens through the processing and presentation of antigens to specific immune cells Discuss the antigen presentation pathways that are used for viral pathogens and extracellular bacterial pathogens. Include the type of MHC used in each pathwayIn adoptive immunotherapy for melanoma, tumor-infiltrated lymphocytes(TILs) are expanded ex-vivo then reinfused into the patient together with IL-2. The rationale for the administration of IL-2 is that it serves as a growth factor for the TILs. Group of answer choices True False