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- 3. Patient XY, who had severe hemophilia A and had recently n=been hospitalized for a bleeding episode in his knee, had a follow-up appointment. The existence of a high-titer factor VIII inhibitory antibody measuring 13 Bethesda units (BU) hampered his hospitalization, necessitating the administration of recombinant factor VIIA to control his bleeding. The possibility of initiating immunological tolerance induction (ITI) to eradicate his inhibitor is being examined as a way to best control future bleeding episodes. The patient inquires if there are any newer medicines on the horizon for hemophilia A bleeding prevention. Those who were given weekly emicizumab prophylaxis has a lower rate of annualized bleeding episodes than those who are not. What is the mechanism of action of emicizumab? a. Recombinant fusion protein that binds activated factor IX and factor X b. Monoclonal antibody that blocks the tissue factor pathway inhibitor (TFPI) c. Monoclonal antibody that inhibits…1. What is/are the importance of testing Rh blood type in the laboratory? 2. Why is Rh system determination essential to pregnant and childbearing women? 3. What are the principal Rh antigens?4) Identify how neoplastic cells might come to the attention of the immune system.
- 1. Give the advantages of using tube method over the slide method. Why do you have to incubate the tube method in Rh typing? 2. Give the clinical importance of determining the Rh status of a patient? 3. Define HDN and explain the effect of Rh(D) antigen. What is the preventive measure of preventing D-negative mothers from forming anti-D? 4. What are the symptoms in Rh-mediated hemolytic transfusion reactions?Discuss the most common immunological mechanismsresponsible for allergies and how these may be treated.1. Patient X was brought to the emergency room by his mother because he was gushing blood from his mouth after a fall that occurred about 6 hours prior. His mother started that he bled for lengthly periods of time from his vaccine sites, but that he had never had any bruishing or hematomas. The patient was taking medicines for an ear infection he had recently. There was no known history of a bleeding disease in the family. Which from the following is helpful for the diagnosis? a.VWF: Factor VIII binding assay b. Collagen binding assay c. VWF: RCoF assay d. Low dose ristocetin induced platelet agglutination (RIPA) 2. Most patient with hemophilia are male however in uncommon causes, female also can have hemophilia. a.True b. False
- 2. Describe the immunoserological characteristics of a hepatitis B-related antigen. 3. Describe the immunoserological characteristics of a hepatitis B - surface antigen.a) Why is testing for rhesus (Rh) antigens and antibodies different from ABO testing?4. identify the appropriate isolation for the patient with a lesion draining infectious material.
- 1. What is the purpose of Rh view bow? What is the optimum temperature for detection of Rh antigen? 2. Give the different types of Rh antigen typing reagents accdg. to the sources. Explain each.1. List as many as possible blood bank serologic tests that are affected by hemolyzed samples (list as many as possible and how) 2. Enumerate and describe the sources of antibodies utilized in the determination of blood group soluble substances.5. The MLT performs patient testing against specific reagent anti-sera and obtains the following results: Anti-e Anti-D 4+ Anti-c 3+ 3+ Anti-C 3+ a) What is this patient's Rh phenotype? Anti-E 0