(38) Following a rattle snake bite, a patient is injected with horse anti-rattlesnake venom serum. Ten days later he has general weakness, headaches, muscular and joint pains, and dark urine. Laboratory studies show proteinuria. Serum concentrations of immunoglobulins are within the reference range, but serum C3 and C4 concentrations are decreased. Which of the following is the most likely pathological process? (A) Anaphylactic Reaction (B) Delayed Hypersensitivity to horse protei (C) Formation of antigen-antibody complexes containing horse proteins and human immunoglobulin (D) Formsation of antigen-antibody complexes containing snake venom proteins and a horse antibody (E) Systemic reaction to snake venom

(38) Following a rattle snake bite, a patient is injected with horse anti-rattlesnake venom serum. Ten days later he has general weakness, headaches, muscular and joint pains, and dark urine. Laboratory studies show proteinuria. Serum concentrations of immunoglobulins are within the reference range, but serum C3 and C4 concentrations are decreased. Which of the following is the most likely pathological process? (A) Anaphylactic Reaction (B) Delayed Hypersensitivity to horse protei (C) Formation of antigen-antibody complexes containing horse proteins and human immunoglobulin (D) Formsation of antigen-antibody complexes containing snake venom proteins and a horse antibody (E) Systemic reaction to snake venom

Basic Clinical Laboratory Techniques 6E

6th Edition

ISBN:9781133893943

Author:ESTRIDGE

Publisher:ESTRIDGE

Chapter4: Basic Immunology And Immunohematology

Section4.7: Rh Typing

Problem 2RQ

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44. Following a rattlesnake bite, a patient is injected with horse anti-rattlesnake venom, serum. Ten days later he has general weakness, muscular and joint pains. Laboratory studies show Proteinuria. Serum concentrations of immunoglobulins are within the reference range, but serum c3 and c4 qare decreased. Which is the most likely pathologic proces (A) Anaphylactic reaction (B) Delayed hypersensititvity to horse proteins (C) Formation of antigen-antibody complexes containing horse proteins and human immunoglobulins (D) Formation of antigen-antibody complexes containing snake venom proteins and horse antibody (E) Systemic reaction to snake venom
If the thymus of an adult experimental animal is removed, the following observations can be made: (a) No immediate effect occurs, and (b) after 1 year, decreases occur in the number of lymphocytes in the blood, the ability to reject grafts, and the ability to produce antibodies. Explain these observations.
How does the general principle of physiology apply at the molecular level in the case of immunoglobulins?
1. The laboratory scientist who reviews the marrow reports that the bone marrow is overridden with plasma cells—so much so that clusters of plasma cells can be seen. What is the function of plasma cells? Explain with no more than 3-6 sentences. A). To present foreign antigens to immune cells B). To directly attack foreign cells when foreign antigens are recognized. C). To phagocytize cells with foreign antigens. D). To produce immunoglobulins specific to foreign antigens presented by T helper cells. 2. Immunoglobulins are made mainly of what substance? Explain. A). Carbohydrate B). Lipid C). Protein
. A) What is the significance of producing monoclonal antibodies? B) What is the role of cell culture in production of monoclonal antibodies? C) Name and briefly explain the use of any 4 commercially available monoclonal antibodies.
Antigen is injected through vaccination into the same site as a previous injection of that same antigen. Antibody-antigen complexes deposit in basement membranes of the epithelial tissues. Neutrophils infiltrate and degranulate, destroying tissue in that localized area. What is the name for this reaction? O 1) granulomatous reaction 2) arthus reaction 3) serum sickness 4) contact dermatitis
If a person is given a transfusion with the wrong blood type, what mechanism of action is responsible for the reaction seen in the body? O 1) IgE binds to mast cells releasing cytokines 2) Antigen-antibody complexes (IgG, IgM and IgA) lodge in basement membranes of tissues, neutrophil degranulation damages the tissues O 3) T cells respond to the inappropriate cells 4) IgG and IgM bind to cells stimulating complement, triggering cell lysis
When determining the blood type and RH factor of a patient in the lab, which blood type and Rh factor is a person whose red blood cells were agglutinated by both anti-A serum and anti-B serum, but not by anti-Rh serum? O a) AB Rh-negative O b) AB Rh-positive O c) O Rh-negative O d) O Rh-positive
T cells can differentiate into 5 different subsets of helper T cells. Answer the following questions for TH1 cells: A) In general, list three unique factors that differentiate the TH1 subset from the other subsets. B) For each of those factors identified in A, provide one specific example that applies to TH1 cells. C) What type of pathogens are targeted by the TH1 cells?
19) Which of the following is correct, in result from kinins and histamines being released in response to tissue damage? A) decrease in fluid to the tissue B) vasoconstriction C) leaked proteins leave the damaged area D) decrease in neutrophils and monocytes E) none of the above
A 10 year old girl is sent to the school nurse one hour after getting a splinter on her right index finger.. Examination of the finger shows the splinter end, extending from the fingertip; the surrounding area is erythematous, Edematous,and tender. Which off the following molecules, has a primary role in mobilizing neutrophils from the vasculature into the area of the splinter? A) complement component 3B B) C-reactive protein C) factor 12( hageman factor) D) fibrinopeptide E) intracellular adhesion molecule one
The classic clinical problem with immunodeficiency disorders is the development of which of the following? (A) hypotension (B) the Rh factor (C) organ rejection (D) severe infections