What is the relative activity of the two structures shown below on the opioid receptor?HOHO.O A is an antagonist, B is an agonistO A is an agonist, B is an inverse agonistO B has increased activity compared toO A is an agonist, B is an antagonistO B has decreased activity compared to A

Opioids are group of morphine- like chemicals medically used as anesthesia and as pain relief. The…

Answered: What is the relative activity of the…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Buprenorphine is a partial agonist at mu opioid receptors and is used for opioid maintenance treatment (OMT) in patients with opioid use disorder (OUD). Buprenorphine is formulated in a product that contains the mu opioid receptor antagonist, naloxone. What is the purpose of naloxone in this formulation? O To increase the magnitude of response to the partial agonist. O To reduce the likelihood that buprenorphine will be injected intravenously. O To delay the response to buprenorphine. O To provide pain relief to the patient who has OUD.
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Overexpression of this receptor in the cells of the adrenal gland causes Cushing's syndrome, a disease caused by the overproduction of cortisol. One strategy that scientists have employed to treat this disease is the use of small molecules that bind to, but do not activate, MC2R. This type of molecule is generically referred to as an antagonist. How can an antagonist bind to the same receptor as ACTH but not activate it? O a. The antagonist can bind covalently while ACTH binds non-covalently O b. The antagonist is only partially complimentary to the binding pocket of MC2R O The antagonist binds to ACTH and blocks it from binding to the receptor properly O d. The antagonist is the exact same structure as ACTH but since it is synthetic it doesn't work One cause of Cushing's syndrome is the inappropriate production of GPCRS in the adrenal gland that are not normally present in those cells. When these receptors are activated they result in the production of cortisol. Which statement about…

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What is the relative activity of the two structures shown below on the opioid receptor? HO HO. O A is an antagonist, B is an agonist O A is an agonist, B is an inverse agonist O B has increased activity compared to O A is an agonist, B is an antagonist O B has decreased activity compared to A