All of the following statements concerning regulatory T cells (Treg) are correct, EXCEPT: The regulatory cytokines produced by regulatory T cells are IL-12 and TGF-B O Thymocytes that recognize self-antigen in the thymus with a certain affinity become natural (central) regulatory T cells O In the periphery T cells that recognize self-antigen in the presence of TGF-B become induced regulatory T cells O A Treg cell can suppress self-reactive lymphocytes that recognize peptides different from that recognized by itself provided that the peptides are derived from the same tissue O A Treg cell can suppress self-reactive lymphocytes that recognize peptides different from that recognized by itself provided that the peptides are presented by the same antigen-presenting cell (APC)

All of the following statements concerning regulatory T cells (Treg) are correct, EXCEPT: The regulatory cytokines produced by regulatory T cells are IL-12 and TGF-B O Thymocytes that recognize self-antigen in the thymus with a certain affinity become natural (central) regulatory T cells O In the periphery T cells that recognize self-antigen in the presence of TGF-B become induced regulatory T cells O A Treg cell can suppress self-reactive lymphocytes that recognize peptides different from that recognized by itself provided that the peptides are derived from the same tissue O A Treg cell can suppress self-reactive lymphocytes that recognize peptides different from that recognized by itself provided that the peptides are presented by the same antigen-presenting cell (APC)

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter12: Body Defenses

Section: Chapter Questions

Problem 15RE

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Which two events are required to activate a cytotoxic T cell? There is more than one answer. O Class II MHC molecules present extracellular antigen for binding on a complementary cytotoxic T cell receptor. O IL-4 is released by a TH1 cell to be bound by a cytotoxic T cell. O Class I MHC molecules presents intracellular antigen for binding on a complementary cytotoxic T cell receptor O IL-2 is released by a TH1 cell to be bound by a cytotoxic T cell.
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Cytotoxic effector T cells also produce inflammatory cytokines such as IFN-g and TNF-a when their T-cell receptor recognizes peptide:MHC on a target cell. One effect of this cytokine secretion is to enhance the ability of CD8 effector T cells to recognize and kill other infected cells in the nearby vicinity. This enhanced activity is due to: The increased production of perforin and granzymes by CD8 cells The up-regulation of MHC class I protein expression by IFN-g The ability of TNF-a to induce vascular leakage The effect of cytokines on promoting target cell apoptosis The effect of IFN-g to enhance viral replication leading to increased viral antigen presentation
Class switching is initiated by T-cell activation via CD40 ligation. You are working with a mouse model that is deficient in CD40L. What kind of phenotype would you expect to see in the mouse? a lack of memory T cells a lack of antibodies of classes other than IgM extremely high concentrations of IgE extremely low concentrations of IgD
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Describe the differences in how an antigen presenting cells (APC) activate a Helper T versus a Cytotoxic T cell.
Which of the following statements is the most accurate concerning lymphocytes? a. T cells and B cells both express TCRs. These are the product of approximately 100 genes. Each lymphocyte expresses only one of the ~100 receptors coded for by these genes, and in the absence of clonal selection the liklihood that two cells express the same receptor is only moderate b. T cells and B cells express TCRs and BCRs respectively. These are the product of genetic recombination and can comprise one of millions of combinations. Each lymphocyte can express 1000s of different receptor variants, maximizing the likelihood that a single adaptive immune cell will recognize pathogen-associated antigens. c. T cells and B cells express TCRs and BCRs respectively. These are the product of genetic recombination and can comprise one of millions of combinations. Each lymphocyte expresses only one of these receptors, and in the absence of clonal selection the liklihood that two cells express the same…
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