A rare recessive allele inherited in a Mendelian mannercauses the disease cystic fibrosis. A phenotypically normal man whose father had cystic fibrosis marries a phenotypically normal woman from outside the family, andthe couple consider having a child.a. Draw the pedigree as far as described.b. If the frequency in the population of heterozygotesfor cystic fibrosis is 1 in 50, what is the chance that thecouple’s first child will have cystic fibrosis?c. If the first child does have cystic fibrosis, what is theprobability that the second child will be normal?

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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A rare recessive allele inherited in a Mendelian manner
causes the disease cystic fibrosis. A phenotypically normal man whose father had cystic fibrosis marries a phenotypically normal woman from outside the family, and
the couple consider having a child.
a. Draw the pedigree as far as described.
b. If the frequency in the population of heterozygotes
for cystic fibrosis is 1 in 50, what is the chance that the
couple’s first child will have cystic fibrosis?
c. If the first child does have cystic fibrosis, what is the
probability that the second child will be normal?

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