A = Control = 100 B = Treatment = 10 FoldChange (FC) = 10/100 = 0.1 log2FC = log2(10)-log2(100) = 3.32 - 6.64 = -3.32 Please describe why log2FC is more informative?
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- During an SAR effort to identify tyrosine kinase inhibitors, it was found that compound 2 was significantly more potent and selective than compound 1. To what might you attribute this improvement in activity and selectivity? Explain. IC-5 micromolar IC-0.1 mromolarAzithromycin can be administered either orally as a slow release of active ingredients (known as extended release) or intravenously (IV) into the bloodstream (known as immediate release). Calculate the appropriate dosage of both extended and immediate release azithromycin for a 17.0 lb patient. Orally administered extended-release azithromycin dosage for a child is 60 mg per kg of body weight. Calculate the dosage in mg of azithromycin for a 17.0 lb child. IV administered immediate-release azithromycin dosage for a child is 10 mg per kg of body weight. Calculate the dosage in mg of azithromycin for a 17.0 lb child.A cat presents with suspected acute, severe sepsis. The veterinarian asks you to draw up a dose of IV gentamicin. The dosage for a cat with acute sepsis is 2.2 mg/kg. Calculate the dose for an 8-lb cat. The concentration of gentamicin is 50 mg/ml. Show me your calculation Please note that: 1Kg= 2.2 lb
- DO NO INC de zeros at the end of decimal numbers. The problems and drug orders are presented for practice only, and actual prescribed factors. Order: Monocid 500 mg Supply: Monocid 1,000 mg Directions: Reconstitute with 2.5 mL of sterile water to yield 325 mg/mL Give: mL 4. Moving to another question will save this response. Type here to search EO 9unt . oard ses B ps 1 dar 12 X 不 4 1 2 3 41 ry 5 79°F 6 N 26 1 point Theory X Q Caring x 4 e.com/courses/1437/external_tools/retrieve?display-full_width&url=https%3A%2F%2Fallsaintsuniver... ✰ 27:26 Time Remaining < Return Next The physician has ordered a large dose of intravenous opioids by continuous infusion. You know that one of the adverse effects of this medicine is respiratory depression. When you assess your patients respiratory status, you find that the rate has decreased from 16 breaths per minute to 10 breaths per minute. What action should you take? 0000 Stimulate the patient in order to increase respiratory rate. Allow the patient to rest comfortably. Report the decreased respiratory rate to the physician Decrease the rate of IV infusion Previous Q Search L 9 K P 0 Next 218 PM 4/1/2024Pharmacodynamic (PD) Response Biomarkers Instructions Group (https://www.ncbi.nlm.nih.gov/books/NBK326791/), a biomarker is used to show that a biological response has occurred in an individual who has been exposed to a medical product or an environmental agent. Match the pharmacodynamic/response biomarker on the left, with the related you can use internet search, FDA According to the FDA-NIH Biomarker Working treatment/disease on the right. Please note that and NIH websites, as well as the on-line library resources. Sweat chloride Response to warfarin treatment International Effect of enzyme replacement therapy for patients with mucopolysaccharidosis type 1 normalized ratio (INR) Response to a B-lymphocyte stimulator inhibitor in patients with systemic lupus erythematosus Viral load Urinary level of glycosaminoglycans Response to cystic fibrosis transmembrane regulator (CFTR) potentiating agents in patients with cystic fibrosis Blood pressure Response to antihyperglycemic agents or…
- What does the acronym TPA stand for and how is TPA used in diagnostic medicine? Explain briefly.Do not include zeros at the end of decimal numbers. The problems and drug orders are presented for practice only, and actual prescribed dosages factors. Order: Rocephin 500 mg IM Supply: Rocephin 1 gram Directions: Reconstitute with 2.1 mL of sterile water to yield 350 mg/mL Give: ML Moving to another question will save this response. Type here to search O E M 90 DELL22:23 1O 000 · 11:24 A9 OB1 r ll l 52% . +964 782 734 3923 2m541139927815107... Patient Encounter Part 3 The pretreatment workup is summarized below. Pathology: 47-year-old female with new diagnosis of infiltrating intraductal adenocarcinoma involving the left breast and regional node. Further tests on tumor samples indicated ER (8%), PR (negative), HER2 (negative), Ki-67 (72%), and grade (poorly differentiated). Intrinsic subtype (luminal B, HER2-negative). Radiology: FDG-PET/CT indicated a 5.3 x 2.5 cm mass in the left breast which appeared to extend to the epidermis of the skin; one node in the left axilla was also involved with tumor. No other evidence of distant disease was visualized. Laboratory: CBC, liver, and kidney function tests WNL, alkaline phosphatase and calcium are normal also. Stage: IB (T, N, M,) List the most important prognostic factors in this patient with newly diagnosed breast cancer. Assess the patient's level of risk for relapse. 50 SECTION 16 | ONCOLOGIC…
- The nurse is preparing to give Acetaminophen to a 5year old girl weighing 20 kg. The doctor has ordered Acetaminophen 240mg PO qehr PRN pain. the safe dose range for acetaminophen is 10-15 MG/KG/dose. What is the low safe amount per dose? [1] What is the high safe amount per dose? (2) is this dose safe to give? (3]Based on the image below, select the correct statement. Complex II QH₂ Q- 10 2 HO 2 HO Fe-S (2.8 FADH₂ FAD- Succinate Fumarate https://canvas.uts.edu.au/assessment questions/356986/files/1562694/download? 2e verifier-eUTT3hYal2YYTWlywV8TIFA3USmzCsM52jECmvTo O Succinate is reduced to fumarate O Succinate is oxidised to FAD O The Fe-S center shuffles electrons from FAD to ubiquinone (Q) O The Fe-S center shuffles electrons from FADH2 to ubiquinone (Q) The Fe-S center shuffles electrons from FADH2 to ubiquinonol (QH2) W 88 16°CBriefly explain this statement -"Therapeutic drug monitoring of Warfarin" Please explain at your own words(500-600 words appropriately).