A 41-year-old man presents to the emergency department complaining of fever, chills, and malaise. A preliminary diagnosis of infective endocarditis is established, and he is started on an intravenous antibiotic administered every 6 hours. The antibiotic follows first-order kinetics and has a volume of distribution of 80 L and a clearance of 1 L/min. How much should be administered every 6 hours to maintain a therapeutic steady-state plasma concentration of 8 mg/L? A. 84 mg B. 126 mg C.1300 mg D. 1720 mg E. 2880 mg

3-2-1 Code It
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Chapter10: Cpt Anesthesia
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A 41-year-old man presents to the emergency department complaining of fever, chills, and malaise. A preliminary diagnosis of infective endocarditis is established, and he is started on an intravenous antibiotic administered every 6 hours. The antibiotic follows first-order kinetics and has a volume of distribution of 80 L and a clearance of 1 L/min. How much should be administered every 6 hours to maintain a therapeutic steady-state plasma concentration of 8 mg/L?

A. 84 mg

B. 126 mg

C.1300 mg

D. 1720 mg

E. 2880 mg

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