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Need help on #5 of my genetic questions
In the disease called “haemophilia”, if a wound is created, the blood does not clot normally. This occurs because the person who suffers from haemophilia lacks sufficient blood clotting factors in his body. This is an inherited disease by which males are affected. Women may be carriers of haemophilia. Among the sex chromosomes, haemophilia is carried by the X chromosome.
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- 2. Hemophilia is an X linked recessive trait. There is a woman who is a carrier for hemophilia and marries a man with hemophilia. a) Complete the Punnett Square (it is a google drawing so you will have to double click it to go to the drawing and type in and around the square. Hold the CONTROL (or Command) button and press the PERIOD button to write a superscript/exponent.) b) What are the possible genotypes of the children? c) Could any of their children have hemophilia? If so, would the child be male or female? Explain your reasoning.6. The pedigree below traces the inheritance of a particular disorder. Circles are females, squares are males. Shaded symbols are affected with the disorder (NOTE: "half-shaded" symbols are NOT used here, for heterozygous individuals). What is the mode of inheritance of this disorder: is it dominant or recessive? Autosomal or X-linked? What is the genotype of the three numbered individuals? 1 2. 3.6. In humans, hemophilia is a recessive and sex-linked character. A man and a woman (grandparents), both normal with respect to blood clotting have: 1 a hemophilic son who has a daughter who is normal; - a daughter who has normal blood and who has one hemophilic and one normal son; and - another daughter with normal blood who has five sons, all normal. What are the probable genotypes of grandparents, children, and grandchildren?
- 6. A person is simultaneously heterozygous for two autosomal genetic traits. One is a recessive condition foralbinism (alleles A and a); this albinism gene is foundnear the centromere on the long arm of an acrocentricautosome. The other trait is the dominantly inheritedHuntington disease (alleles HD and HD+). TheHuntington gene is located near the telomere of oneof the arms of a metacentric autosome. Draw all copies of the two relevant chromosomes in this person asthey would appear during metaphase of (a) mitosis,(b) meiosis I, and (c) meiosis II. In each figure, labelthe location on every chromatid of the alleles forthese two genes, assuming that no recombinationtakes place.4. Hemophilia in cats is X-linked recessive. (And yes, cats' sex chromosomes work the same way peoples' do.) A carrier lady cat marries a hemophilic man cat. a) Draw a Punnett square showing this, and showing offspring genders and genotypes. Hint: you must draw the correct type of Punnett square for an x-linked problem to get the right answer. b) What fraction of their boy kittens will be hemophilic? c) What fraction of their girl kittens will be hemophilic? d) What fraction of all their kittens will be hemophilic? e) A daughter from this marriage grows up and gets married to a hemophilic tomcat. All of their kids are hemophilic. What was the genotype of the daughter?8. Consider the following phenotype for hemophilia, a recessive X-linked blood clotting disorder, in decendents of Queen Victoria. Victoria is thought to have been a carrier for the recessive hemophilia allele. What is the probability that Princess Irene is also a carrier? Albert Victoria (1819–1901) Edward Empress Victoria Leopold Princess O O L Duke of Alice Helena Beatrice II of Hesse Christian Albany Kaiser George Princess Frederick (Alexandra) Victoria Leopold Maurice Eugenie Alice Wilhelm II V Irene Alix Tsarina of Athlone Nikolas II (wife of Alfonso XIII)
- 6. Hemophilia causes severe bleeding from minor wounds. The blood is unable to clot properly because one of the factors necessary for clotting is missing. Hemophilia is an inherited sex-linked recessive disorder transmitted on the X chromosome by mothers to their sons. i) A woman inherited the gene for hemophilia from her mother and marries a man who iş normal and has no hemophilia. What is the possibility that her children can have hemophilia?5. The pedigree below traces the inheritance of Albinism, a genetic disorder. Affected individuals, indicated here by the coloured circles and squares, are unable to make a normal amount of melanin, the chemical that is responsible for eye, skin, and hair colour. Does Albinism appear to be caused by a dominant allele or by a recessive allele? Fill in the genotypes of the individuals whose genotypes can be deduced. What genotypes are possible for each of the other individuals? Explain! Naruto Hinata Reiner Asta Hange Mikasa Eren Historia Luffy Nezuko Zenitsu Tanjiro Son Goku3. The recessive sex-linked gene (h) prolongs the blood-clotting time, resulting in the genetically inherited disease called hemophilia. From the information in the pedigree chart (right), answer the following questions: Hemophilia in humans (a) If 112 marries a normal man, what is the probability of her first child being a hemophiliac? 2 (b) Suppose her first child is actually a hemophiliac. What is the chance that her second child will be a boy with hemophilia? 2 (c) If I14 has children with a hemophiliac man, what is the probability that her first child will be phenotypically normal? (d) If the mother of 12 was phenotypically normal, what phenotype was her father? 4. The phenotypic expression of a dominant gene in Ayrshire cattle is a notch in the tips of the ears. In the pedigree chart on the right, notched animals are represented by the solid symbols. Ear notches in Ayrshire cattle Determine the probability of notched offspring being produced from the following matings: 1 2 (a)…
- 1. Hair or fur length in cats is controlled by a single, autosomal gene; the short hair-allele is dominant to the allele for long hair. Hair color is produced by a different gene which is located on the X chromosome. One allele for this sex-linked gene produces yellow, while an alternate allele produces black fur color; individualswhich are heterozygous for these alleles are calico or tortiseshell in color.If a long-haired, black male is mated with a calico female homozygous for short hair what kind of kittens will be produced in the Ej generation? Give both genotypes and phenotypes; express the genotypes bothsymbolically and in words. Label answers clearly!!1. Red-green colorblindness is caused by a recessive allele (x) at an X-linked gene, and albinism is caused by a recessive allele (a) at an autosomal gene. A phenotypically normal woman (Sara) has a father who is colorblind, and she knows that she is a carrier for albinism. She plans to have a child with a colorblind man (Abdul) who is also a carrier for albinism. What is the probability that Sara and Abdul's child will have one of the conditions, but not both? (C. Follow the steps below to answer this question. a) What is the cross? b) What are the target genotypes? Note: it might be useful to come back to this one and double- check it after you have completed step c, below. Break this down to the single gene level by answering the following questions: a. What is the proportion of normal to albino offspring? Show the Punnett square: b. What is the proportion of normal to colorblind offspring? Show the Punnett square: d) What is the probability that Sara and Abdul's child will have one…9. Red-green color blindness is inherited as an X-linked recessive (Xc). If a color-blind man marries a woman who is heterozygous for normal vision, what would be the expected phenotypes of their children with reference to this character? In your answer, specify in your phenotype descriptions the gender of the children. (For example, don’t just say 75% of the children would be colorblind – you would instead say 100 % of the daughters would be colorblind and 50% of the sons would be colorblind. Note that this is not a correct answer; it is just to give you an idea of how to explain the correct phenotypes of the cross.)___