You are trying to come up with a drug to inhibit the activity of an enzyme thought to have a role in liver disease. In the laboratory the enzyme was shown to have a Km of 1.0 x 10-6 M and Vmax of 0.1 micromoles/min.mg measured at room temperature. You developed a competitive inhibitor. In the presence of 5.0 x 10-5 M inhibitor, the apparent Km of the enzyme was found to be 1.5 x 10-5 M. What is the Ki of the inhibitor?
You are trying to come up with a drug to inhibit the activity of an enzyme thought to have a role in liver disease. In the laboratory the enzyme was shown to have a Km of 1.0 x 10-6 M and Vmax of 0.1 micromoles/min.mg measured at room temperature. You developed a competitive inhibitor. In the presence of 5.0 x 10-5 M inhibitor, the apparent Km of the enzyme was found to be 1.5 x 10-5 M. What is the Ki of the inhibitor?
Chapter30: Kinetic Methods Of Analysis
Section: Chapter Questions
Problem 30.1QAP
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You are trying to come up with a drug to inhibit the activity of an enzyme thought to have a role in liver disease. In the laboratory the enzyme was shown to have a Km of 1.0 x 10-6 M and Vmax of 0.1 micromoles/min.mg measured at room temperature. You developed a competitive inhibitor. In the presence of 5.0 x 10-5 M inhibitor, the apparent Km of the enzyme was found to be 1.5 x 10-5 M. What is the Ki of the inhibitor?
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