You are testing a compound as cardioactive drug. You know the compound is an agonist of acetylcholine (ACh) at the relevant ACh receptor (AChR) on sinoatrial (SA) node cells. Briefly describe how the action of the drug likely would affect the electrical signal produced by the SA node cells. In respect of cardiac output, what would you expect to be the effect of this drug?
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- Cells in the body have the ability to undergo a transiet depolarization and repolarization. A. Plot the action potential of non-pacemaker cardiac myocyte and indicate what kinds of ion channels involved in each phase and compare ion movement during a myocardial cell's action potential to ion movement of a neuron's action potential. B.Explain why contractions in the cardiac muscle cells are different to skeletal muscle cells.In a standard EPS, briefly explain what is the difference between the used terms of “fixed pacing” and “pacing after sensing”, in the study part for testing inducibility to ventricular tachycardia (VT).Describe why a doctor would give a patient that is diagnosed with acute myocardial infarction the treatment of tissue plasminogen activator(tPA)? What will it do?
- Consider the ventricular cardiomyocyte action potential shown below: a) Which phase of the cardiac myocyte action potential would be most significantly affected by the L-type calcium channel blocker nifedipine? b) Draw the predicted effects of nifedipine on the cardiac myocyte action potential.In a sheet of ventricular cardiac muscle tissue, we should be able to observe electricity spreading between adjacent muscle cells (TRUE or FALSE) and from Purkinje fibers to muscle cells (TRUE or FALSE) via electrical synapses that form between the cell membranes.In the nineteenth century, Poiseuille’s law was experimentally deduced byJ. L. M. Poiseuille, who was interested in understanding the flow of blood inhorses’ arteries.We nowknowthat Poiseuille’s lawis a poorway of modelingblood flow in arteries. In your own words, give at least three reasons whyPoiseuille’s lawis not appropriate for arterial blood flowmodeling, and brieflydiscuss why this is the case.
- In a standard EPS, briefly explain what is the difference between “pacing after sensing” and “fixed pacing”; in the study of inducibility to ventricular tachycardia (VT)?A cardiologist observed an cntargc4 QRS wave in the ECU of a patient. What does it indicate?I need to calculate the approximate heart rate based on the given ECG results, but I can't get how to determine the length of time between two consecutive R waves. What I see, it's one second between the two highest waves (I suppose they are R waves). But it means the heart rate should be 60 beats per minute, but there is no option for this answer. Teach me how to determine correctly the length of time between two consecutive R waves.
- Discuss TWO (2) body surface electrodes that can record the bioelectric potential of the heart activity.Select the TRUE statement/s: Calcium channel blocker will affect which phase/s of the cardiac muscle cell action potential? Copyright © McGraw-Hill Education. Permission required for reproduction or display. +30- Membrane potential (mv) +10. -10- -30- -50- -70- -90 0 O A) Phase 1 OB) Phase 2 OC) Phase 3 (b) Electrical events at the sarcolemma of a cardiac muscle cell OD) Phase 4 3 0.15 Time (seconds) OE) All of the above RMP 0.30We analyzed the difference between the action potential of a cardiac contractile cell and an action potential in a neuron. Describe the physiological mechanisms behind the primary difference in the shape of these two action potentials. Why is this feature important to the normal workings of the heart?