You are studying a new retrovirus. The viral protein (X) appears to play a role in the export of the viral genomes to thecytoplasm. Protein X brings viral DNA to the cytoplasm and returns back to the nucleus after genome export is complete.Researchers have developed a new drug for the virus. Following treatment with the new drug, the viral protein stays in thenucleus and cannot export the viral genomes. What is the most plausible and logical function of the drug? Use yourknowledge of nuclear transport to answer this question.O A. The drug inhibits the binding of the viral protein and the viral genomes to the import receptor.B. The drug inhibits the binding of Ran-GTP to the nuclear export receptor in nucleus.C. The drug promotes the Ran GAP activity.D. The drug blocks the NLS on the viral protein.

The nucleus is the structure that encompasses the genome (DNA) in all eukaryotic cells. It is…

Answered: You are studying a new retrovirus. The…

Phlebotomy Essentials

6th Edition

ISBN:9781451194524

Author:Ruth McCall, Cathee M. Tankersley MT(ASCP)

Publisher:Ruth McCall, Cathee M. Tankersley MT(ASCP)

Chapter1: Phlebotomy: Past And Present And The Healthcare Setting

Section: Chapter Questions

Problem 1SRQ

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Some retroviruses that have a wide host range have been developed for use in treatment of diseases or syndromes. These viruses do not result in a productive infection because they lack critical genes for viral replication, but they do carry DNA sequences that allow them to be packaged into infectious particles. Once in the host cell the viral DNA is released and integrates into the cell's genome. The advantage to this strategy is that the delivery of the DNA is very efficient. What is one possible problem of using a virus that can integrate into the human nuclear genome? Multiple Choice The virus carries genes that will interfere with host cell activities. The viral DNA sequences could still cause a disease. Since the viral DNA sequences no longer contain essential genes for viral replication the host cell may not be able to replicate either. The integration could disrupt an essential gene or genes.
Viruses with negative sense RNA genomes typically, make proteins by: (Ignore retroviruses, and the unusual characteristics of coronaviruses) Translation of short RNA transcripts generated by RDRP Generating a DNA copy, which is then transcribed by host RNA polymerase. Translation of the viral genome by host ribosomes. Production of a polyprotein, which must be cleaved into smaller proteins. Generating a negative sense genome copy, which is then translated by host ribosomes.
Viruses are host-specific, meaning they can only infect specific types of host organisms. For examble, the adenovirus is responsible for the common cold in humans but your dog can't catch a cold from you. Why is this? The proteins on the virus surface can only bind with proteins on the correct host surface. It is an enveloped or non-enveloped virus. The enzymes carried by the virus are compatible with the host. The genome of the virus is made of DNA or RNA.
‘’Viruses cannot be grown in standard microbiological culture such as broth and agar. They need to be cultured in the presence of a suitable host such as prokaryotic cells (easiest to grow in the lab), plants and animals because they are unable to reproduce independently in living cells’’.2.2 What are the changes that are brought by a virus to a cell? In your response, make reference to the cytopathic effect (CPE).
After a positive strand RNA virus ( Such as Coronaviruses) enters the host cell, the RNA is translated by ribosomes to create proteins associated with the virus (Such as, for example, the surface antigens like E and Spike proteins). How then, would the genetic material itself be replicated to be incorporated into the new viruses?.
1. Precise words:Find the nonspecific terms in the following sentences. Replace the nonspecific choices with more preciseterms or phrases (It is not necessary to change the sentence structure).(i) All OVE mutants showed enhanced iP concentrations.(ii) Plants were kept in the cold overnight.(iii) To provide proof of concept for our hypothesis, we studied a virus in its host cell.(iv) The present paper reports on continuing experiments that were performed to clarify thissurprising effect.(v) The first transition state is a little lower in energy than the second transition state. 2. Simple words:Improve the word choice in the following examples by replacing the underlined terms or phrases withsimpler word choices (do not change the sentence structure).(i) These data substantiate our hypothesis.(ii) The difference in our results compared to those of Reuter et al. (1995) can be accounted forby the fact that different conditions were used.(iii) For the purpose of discussing cell migration we…
Assume you isolate a single stranded (+) RNA virus. When you examine the proteins in the virus, you find that it does NOT contain replicase enzymes within its capsid. Which of the following is true? This virus must have a gene that encodes replicase. This virus will not be able to enter a host cell. Its genome cannot be translated (the process of translation) by the host cell ribosomes. A DNA copy of the viral genome has to be made before viral genes are expressed. This virus must lack surface antigens.
Coronaviridae is a virus “family.” There are actually many different coronaviruses within this group, including less pathogenic virus strains that cause the common cold. Many people in this course have likely been infected with one of these other coronaviruses. A common feature of coronaviruses and other RNA viruses (think influenza virus, HIV, etc.) is that they mutate frequently. This is because the viral enzymes that copy the genome during replication can’t fix mistakes. Given this information, how might we be able to distinguish the SARS-CoV-2 strain from some of the other, less concerning, coronavirus strains?
All viral genomes contain nucleic acid, either DNA or RNA but not both. Viral replication is the formation of biological viruses during the infection process in the target host cell. Viruses must first enter the host cell before viral replication can occur. After gaining entry into a cell, the viral genome has to be first replicated using either the host DNA polymerase or RNA polymerase You are studying two viruses: Virus A is an enveloped RNA virus Virus B is non-enveloped DNA virus Which of the above viruses is likely to have the lowest mutation rate in the host cell? O Virus A because it uses the host RNA polymerase which has lower error rate than DNA polymerase. O Virus A because it uses the host DNA polymerase which has lower error rate than RNA polymerase. O Virus B because it uses the host DNA polymerase which has lower error rate than RNA polymerase. O Virus B because it uses the host RNA polymerase which has lower error rate than DNA polymerase.
You have discovered a new disease-causing virus. It has a negative sense RNA genome. Infected individuals often have few-to-no symptoms, but are continuously infectious to other individuals for months after initial infection. Which of the following is likely true about this virus? (Select all that apply) Its genome must first circularize before being translated into proteins It carries a replicase protein into a host cell upon infection. The symptoms of this virus exemplify a latent infection. The virus has infected every cell within an infected individual. The virus must first synthesize the complementary strand RNA before expressing new proteins. The symptoms of this virus exemplify a chronic infection.
Viruses variously depend on their host cell for parts of the viral replication and maturation process. Many viruses do however encode for some enzymes that facilitate certain steps or virus-specific processes for viral replication and maturation. Which cellular processes and enzymes do all viruses lack and must therefore ALWAYS be supplied by the host cell?
Viruses may be latent for a long period of time. For example, HIV may be latent for many years, during which new viruses are not made. What are three different mechanisms of viral latency?

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